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© 1994 Oxford University Press

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MIC2R: a transcribed MIC2-related sequence associated with a CpG island in the human pseudoautosomal region

Matthijs J. Smith* and Peter N. Goodfellow1

Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children's Hospital Flemington Road, Parkville 3052, Victoria, Australia 1Department of Genetics, University of Cambridge Downing Street, Cambridge CB2 3EH, UK

*To whom correspondence should be addressed

Received April 22, 1994; Revised July 12, 1994; Accepted July 12, 1994

Sequences related to exons 1, 4 and 5 of the human pseudoautosomal gene MIC2 have been detected on the X and Y chromosomes of humans and other primate species. Isolation of these sequences has defined a new transcribed locus, MIC2R (MIC2-related) which is associated with the second most proximal CpG-rich Island in the human pseudoautosomal region. Genomic sequences from the MIC2R locus show that it is composed of a single sequence related to exon 1 and at least four tandem copies of sequences related to exons 4 and 5 of MIC2. Comparison of the four exon 4- and 5-related sequences suggest that they are the result of sequential duplication of a 2.8 kb region during evolution. Transcripts from the MIC2R locus have been detected in all tissues analysed and a number of different transcripts appear to be generated by alternative RNA splicing. However, as none of the transcripts analysed to date contain a significant open reading frame, the function of the MIC2R locus remains unknown.


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