Human Molecular Genetics, Vol 3, 1449-1452, Copyright © 1994 by Oxford University Press
AC Chandley and HJ Cooke
Using a positional cloning approach, we have isolated a new gene family,
the Y-located RNA Recognition Motif genes (YRRM), which constitutes a
candidate for AZF, the 'azoospermia factor' located principally within band
Yq11.23, and thought to be important in the control of human
spermatogenesis. The YRRM gene family has at least 15 members, more than
one of which are transcribed, some of which are pseudogenes. RNA in situ
hybridization to adult human testis tissue indicates that gene expression
of the YRRM family is confined to germ cells, notably spermatogonia and/or
primary spermatocytes. Similar patterns of hybridization are seen for a
second gene family, TSPY, clustered mainly on the short arm of the human Y
chromosome. Both YRRM and TSPY show Y chromosome conservation in several
mammalian species.
REVIEWS
Human male fertility--Y-linked genes and spermatogenesis
MRC Human Genetics Unit, Western General Hospital, Edinburgh UK.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Jarvis, D. J. Elliott, D. Morgan, R. Winston, and C. Readhead Molecular markers for the assessment of postnatal male germ cell development in the mouse Hum. Reprod., January 1, 2005; 20(1): 108 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Blagosklonova, C. Joanne, C. Roux, H. Bittard, F. Fellmann, and J.L. Bresson Absence of anti-Mullerian hormone (AMH) and M2A immunoreactivities in Sertoli cell-only syndrome and maturation arrest with and without AZF microdeletions Hum. Reprod., August 1, 2002; 17(8): 2062 - 2065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Jaruzelska, A. Korcz, A. Wojda, P. Jedrzejczak, J. Bierla, T. Surmacz, L. Pawelczyk, D. C Page, and M. Kotecki Mosaicism for 45,X cell line may accentuate the severity of spermatogenic defects in men with AZFc deletion J. Med. Genet., November 1, 2001; 38(11): 798 - 802. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tascou, K. Nayernia, A. Samani, J. Schmidtke, T. Vogel, W. Engel, and P. Burfeind Immortalization of Murine Male Germ Cells at a Discrete Stage of Differentiation by a Novel Directed Promoter-Based Selection Strategy Biol Reprod, November 1, 2000; 63(5): 1555 - 1561. [Abstract] [Full Text]
|
|
|
|
 |
|
 O. Blagosklonova, F. Fellmann, M.-C. Clavequin, C. Roux, and J.-L. Bresson AZFa deletions in Sertoli cell-only syndrome: a retrospective study Mol. Hum. Reprod., September 1, 2000; 6(9): 795 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dadze, C. Wieland, S. Jakubiczka, K. Funke, E. Schroder, B. Royer-Pokora, R. Willers, and P.F. Wieacker The size of the CAG repeat in exon 1 of the androgen receptor gene shows no significant relationship to impaired spermatogenesis in an infertile Caucasoid sample of German origin Mol. Hum. Reprod., March 1, 2000; 6(3): 207 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ferlin, E. Moro, A. Garolla, and C. Foresta Human male infertility and Y chromosome deletions: role of the AZF-candidate genes DAZ, RBM and DFFRY Hum. Reprod., July 1, 1999; 14(7): 1710 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Elliott, M. R. Millar, K. Oghene, A. Ross, F. Kiesewetter, J. Pryor, M. McIntyre, T. B. Hargreave, P. T. K. Saunders, P. H. Vogt, et al. Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm PNAS, April 15, 1997; 94(8): 3848 - 3853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Foresta, A. Ferlin, A. Garolla, M. Rossato, S. Barbaux, and A. De Bortoli Y-Chromosome Deletions in Idiopathic Severe Testiculopathies J. Clin. Endocrinol. Metab., April 1, 1997; 82(4): 1075 - 1080. [Abstract] [Full Text] [PDF]
|
|