Human Molecular Genetics, Vol 3, 1509-1517, Copyright © 1994 by Oxford University Press
S Tugendreich, DE Bassett Jr, VA McKusick, MS Boguski and P Hieter
Evolutionary conservation of homologous gene products from distantly
related organisms provides an information resource of great value for
elucidating protein structure and function. Sequence similarities also
serve as molecular cross-references between diverse organisms that offer
different, or complementary, experimental approaches for analyzing gene
expression and biochemistry in normal and abnormal states. There are now
countless examples of information about a protein from one species
contributing to the understanding of biological phenomena or disease in
another species. Such connections are often unanticipated and surprising,
but there is an opportunity to make them more systematically as concerted
genome sequencing projects progress. In the present review we focus on
connections between yeast and human proteins and their functional
implications. We present several 'case studies' as well as survey results
derived from comprehensive sequence comparisons among all yeast and human
proteins currently present in the public databases.
REVIEWS
Genes conserved in yeast and humans
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185.
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