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© 1995 Oxford University Press

Localization of the gene for congenital dyserythropoietic anemia type III, CDAN3, to chromosome 15q21-q25

Lisbet Lind*, Herbert Sandström1, Anders Wahlin2, Mikael Eriksson3, Birgitta Nilsson-Sojka4, Carin Sikström5 and Gösta Holmgren

Departments of Clinical Genetics/Cell and Molecular Biology 1 1Family Medicine 2 internal Medicine 3 Oncotogy 4 Transfusion Medicine, University Hospital 5 Department of Medical Genetics, Umeà University, S-901 85 Umeà Sweden

*To whom correspondence should be addressed

Received August 25, 1994; Revised October 26, 1994; Accepted October 26, 1994

Congential dyserythropoietic anemia, type III (CDA III) is a rare autosomal dominant disorder characterized by macrocytic anemia, bone marrow erythroid hyperplasia and giant multlnucleate erythroblasts. We have genetically characterized a large Swedish family in which the concurrence of CDA III and myeloma or benign monoclonal gammopathy is significantly higher than expected and have found that the causative genetic defect for CDA III maps to an 11 cM interval within 15q21–q25.


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