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© 1995 Oxford University Press

RESEARCH-ARTICLE

An integrated physical and genetic map of a 35 Mb region on chromosome Xp22.3–Xp21.3

Glovanni B. Ferrero1,2, Brunella Franco1,2,+, E.Jill Roth3, Beth A. Firulli1,2, Gluseppe Borsanl1,2,+, Juan Delmas-Mata1,2, Jean Weissenbach4, George Halley5, David Schlessinger5, A.Craig Chinault1,2, Huda Y.Zoghbi1,2,3, David L.Nelson1,2 and Andrea Ballabio1,2,6,+,*

1Human Genome Center Houston, Texas, USA 2Department of Molecular and Human Genetics Houston, Texas, USA 3Department of Pediatrics, Baylor College of Medicine Houston, Texas, USA 4Genethon Evry Cedex, France 5Center for Genetics in Medicine, Washington University School of Medicine St Louis, Missouri, USA 6Department of Molecular Biology, University of Siena Siena, Italy

*To whom correspondence should be addressed

Received May 18, 1995; Revised July 7, 1995; We have constructed a detailed physical map of the 35 Mb region spanning human chromosome Xp22.3–Xp21.3. The backbone of the map is represented by a single oriented contiguous stretch of 585 overlapping yeast artificial chromosome (YAC) clones covering the entire region. The map is formatted with 615 map objects that include 324 YACs, 185 sequence tagged sites, 28 genes, 85 chromosomal breakpoints and 37 highly polymorphic markers. Physical mapping was both guided and confirmed using 183 bins defined by chromosomal breakpoints and by overlapping regions of YAC clones. The localization of polymorphic markers in the physical map permits the integration of physical and genetic data across the region. These data establish chromosome Xp22.3–Xp21.3 as one of the best characterized large regions in the human genome. The map should greatly facilitate finer scale mapping and sequencing as well as the identification of disease genes from this portion of the human genome.

+Present address: Telethon Ins of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Via Olgenina 58, 20132 Milano, Italy


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