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© 1995 Oxford University Press

RESEARCH-ARTICLE

A collection of tri- and tetranucleotide repeat markers used to generate high quality, high resolution human genome-wide linkage maps

Val. C. Sheffield1,*, James L. Weber3, Kenneth H. Buetow4, Jeffrey C. Murray1,2, Dee Ann Even1, Kerry Wiles1, Julie M. Gastier5, Jacqueline C. Pulido5,6, Chandri Yandava5, Sara L. Sunden1, Gretel Mattes1, Thomas Businga1, Anne McClain1, John Beck1, Titia Scherpler4, John Gilliam4, John Zhong4 and Geoffrey M. Duyk5,6

1Cooperative Human Linkage Center (CHLC) and Departments of Pediatrics 2Cooperative Human Linkage Center (CHLC) and Departments of Biology Division of Medical Genetics, University of Iowa 200 Hawkins Drive, Iowa City, IA 52242 3Cooperative Human Linkage Center (CHLC) and Departments of Marshfield Medical Research Foundation Marshfield, WI 54449 4Cooperative Human Linkage Center (CHLC) and Departments of Fox Chase Cancer Center Philadelphia PA, 19111 5Cooperative Human Linkage Center (CHLC) and Departments of Genetics 6Cooperative Human Linkage Center (CHLC) and Departments of Hughes Medical Institute, Harvard Medical School Boston, MA 02115, USA

*To whom correspondence should be addressed

Received May 24, 1995; Revised July 14, 1995; We report a collection of tri- and tetranucleotide repeat sequence polymorphic markers used to construct genome-wide human linkage maps. Using a strategy of marker selection to create libraries highly enriched for the presence of specific tandem repeat elements, we have developed over 2000 high heterozygosity, easy-to-use tn- and tetranucieotide short tandem repeat polymorphisms (STRPs). To date, over 1300 of these markers have been genotyped on the CEPH reference families. Additional STRPs were assigned to chromosomes using human monochromosomal somatic cell hybrids. The linkage maps constructed with these markers have been integrated with other CEPH genotypes into a comprehensive high density linkage map. These STRPs have been shown to be robust for genotyping in a variety of laboratories using a variety of methods. The high quality of these STRPs makes them ideal candidates for use in genome-wide linkage searches. The integration of these markers with physical mapping reagents and other genetic markers will create a resource for moving from genome-wide linkage searches to rapid subiocalization of disease loci.


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