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© 1995 Oxford University Press

OTHER

Candidate regions for a testicular cancer susceptibility gene

Michael G. Leahy1,2,*, Susan Tonks1, Jonathan H. Moses1, A.Rosemary Brett3, Robert Huddart5, David Forman3,+, R.Timothy D. Oliver2, D.Timothy Bishop4 and Julia G. Bodmer1

1Tissue Antigen Laboratory, Imperial Cancer Research Fund 44 Lincoln's Inn Fields, PO Box 123, London WC2A 3PX 2Department of Medical Oncology, London Hospital Medical College Turner Street, London E1 1BB 3ICRF Cancer Epidemiology Unit, Gibson Building, Radcliffe Infirmary Oxford 0X2 6HE 4ICRF Genetic Epidemiology Laboratory, Ashley Wing, St James's University Hospital Beckett Street. Leeds LS9 7TF 5Section of Molecular Carcinogenesis, Haddow Laboratories, Institute of Cancer Research Cotswold Road, Sutton, Surrey SM2 5NG, UK

*To whom correspondence be addressed

Received March 21, 1995; Revised June 21, 1995; Accepted June 21, 1995

Epidemiological data suggest the presence of a susceptibility gene for testicular cancer in some families. Families with multiple cases of testicular cancer are rare and almost all those reported have only two affected members. We have performed a sib-pair analysis on 35 families in which there are either two or three affected brothers. These families have been typed for 220 autosomal microsatellite markers spaced 10–20 cM throughout the genome. Six regions which gave a LOD score of more than 1.0 on formal linkage analysis or a P value of 0.05 or less using a non-parametric approach are considered as candidate regions for a susceptibility gene. Of particular interest is one region on chromosome 4. Two neighbouring probes in this region both scored positively with LOD score of 2.60 on multipoint analysis. An International Testis Cancer Linkage Consortium has been formed to pool resources and will investigate these findings further with the world-wide collection of families.

+Present address: Yorkshire Cancer Registry, Yorkshire Cancer Organisation, Cookridge Hospital, Leeds LS16 6QB, UK


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