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© 1995 Oxford University Press

OTHER

Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect?

Stephen C.L. Gough, Philip J. Saker1, Lynn E. Pritchard, Tony R. Merriman, Marilyn E. Merriman, Bethan R. Rowe2, Sudhesh Kumar2,3, Timothy Aitman4, Anthony H. Barnett2, Robert C. Turner1, Stephen C. Bain2 and John A. Todd*

Nuffield Department of Surgery, Windmil Road, The Wellcome Trust Centre for Human Genetics Headington, Oxford 0X3 7BN 1Diabetes Research Laboratories, Radcliffe Infirmary Woodstock Road, Oxford, 0X2 6HE 2Department of Medicine/Diabetes/Endocrinology, University of Birmingham, Heartlands Hosptial Bordesley Green East, Birmingham B9 5SS 3Department of Medicine, Manchester Royal Infirmary Manchester 4MRC Clinical Sciences Centre, Hammersmith Hospital Du Cane Road, London W12 ONN, UK

*To whom correspondence should be addressed

Received May 5, 1995; Revised June 23, 1995; Accepted June 23, 1995

Recent evidence suggests that a mutation of the glucagon receptor (GCG-R) gene is involved in the development of type 2 diabetes in French patients. We have examined patients from three geographically distinct regions in the UK and found the GGT40 (Gly) to AGT40 (Ser) mutation to be present in 15/691 (2.2%) of patients with type 2 (non-insulin dependent) diabetes and 1/425 (0.2% ) of geographically matched controls and have therefore replicated association of the GCG-R mutation with classical type 2 diabetes (Fisher's exact test p = 0.008). An increased frequency of the mutation of the GCG-R gene was also found in probands of type 1 (insulin dependent) diabetic multiplex (affected sib pair) families, (10/404, 2.5%). However, a lack of preferential transmission from parents heterozygous for the mutation, to affected type 1 diabetic sibs may suggest population stratification. This in turn cannot be excluded as an alternative explanation for the difference in frequency of the GCG-R gene mutation between subjects with type 2 diabetes and normal controls.


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