© 1995 Oxford University Press
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The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous
1Laboratories of Cellular Immunology and Developmental Genetics, National Institute for Medical Research Mill Hill, London NW7 1AA, UK 2GERM, INSERM unit 435, University of Rennes 35042 Cedex, France
*To whom correspondence should be addressed
Revised May 26, 1995; Accepted May 26, 1995
During an investigation of the regulatory potential of a region 5' of the mouse anti-Müllerian hormone (Amh) gene, we identified a region of homology with the known cDNA sequence of a human spliceosome gene (SAP62). In mouse, the Sap62termination codon (TGA) is just 434 bp 5' of the Amh start of translation (ATG); in the human the equivalent distance is 789 bp. RNase protection analysis shows the majority of Sap62 transcripts use an uncommon polyadenylation signal (ATTAAA) lying in the intragenic region, 87 bp 3' of the TGA. This analysis also shows that Sap62 is transcribed in all tissues examined, whereas specific Amh transcription initiating 10 bp 5' of the ATG is limited to the developing testis of the fetus from 11. 5 days post coitum and in the ovary from 3 days post partum. However, in all tissues a significant number of Sap62 transcripts fail to polyadenylate in the intragenic region and continue through the Amh locus. This implies that the Amh locus is in an open chromatin state in all tissues despite a requirement for precise regulation. Human SAP62 can now be mapped to HSA 19p and mouse Sap62 to MMU10.
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