© 1995 Oxford University Press
OTHER |
Familial non-specific dementia maps to chromosome 3
1Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School London W2 1PG, UK 2Department of Medical Genetics, Panum Institute, University of Copenhagen Copenhagen, Denmark 3Department of Neurology, St Mary's Hospital London W2 1NY, UK 4Suncoast Alzheimer's Disease Laboratories, Departments of Psychiatry Pharmacology, Neurology and Biochemistry, University of South Florida, MDC14, Tampa, FL 33613, USA
*To whom correspondence should be addressed
Received April 10, 1995; Accepted May 26, 1995
A significant minority of degenerative dementias lack distinctive inclusion bodies, plaques or tangles on pathological examination. Half of these cases have a positive family history of dementia. We have studied the largest published family with such a dementia and mapped the disease locus to a 12 cM region of chromosome 3 spanning the centromere. Haplotype analysis demonstrates a common region shared between all affected individuals between the markers D3S1284 and D3S1603. Like a number of other late onset neurodegenerative diseases, the disease presents at an earlier age when paternally inherited.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. van der Zee, H. Urwin, S. Engelborghs, M. Bruyland, R. Vandenberghe, B. Dermaut, T. De Pooter, K. Peeters, P. Santens, P. P. De Deyn, et al. CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro Hum. Mol. Genet., January 15, 2008; 17(2): 313 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Goldman, J. Adamson, A. Karydas, B. L. Miller, and M. Hutton New Genes, New Dilemmas: FTLD Genetics and Its Implications for Families American Journal of Alzheimer's Disease and Other Dementias, January 1, 2008; 22(6): 507 - 515. [Abstract] [PDF]
|
|
|
|
|
|
K. Talbot and O. Ansorge Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease Hum. Mol. Genet., October 15, 2006; 15(suppl_2): R182 - R187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. van der Zee, R. Rademakers, S. Engelborghs, I. Gijselinck, V. Bogaerts, R. Vandenberghe, P. Santens, J. Caekebeke, T. De Pooter, K. Peeters, et al. A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD Brain, April 1, 2006; 129(4): 841 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gydesen, J.M. Brown, A. Brun, L. Chakrabarti, A. Gade, P. Johannsen, M. Rossor, T. Thusgaard, A. Grove, D. Yancopoulou, et al. Chromosome 3 linked frontotemporal dementia (FTD-3) Neurology, November 26, 2002; 59(10): 1585 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M D Greicius, M D Geschwind, and B L Miller Presenile dementia syndromes: an update on taxonomy and diagnosis J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 691 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Riemenschneider, J Diehl, U Muller, H Forstl, and A Kurz Apolipoprotein E polymorphism in German patients with frontotemporal degeneration J. Neurol. Neurosurg. Psychiatry, May 1, 2002; 72(5): 639 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Filla, G. De Michele, S. Cocozza, A. Patrignani, G. Volpe, I. Castaldo, G. Ruggiero, V. Bonavita, C. Masters, G. Casari, et al. Early onset autosomal dominant dementia with ataxia, extrapyramidal features, and epilepsy Neurology, March 26, 2002; 58(6): 922 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. SNOWDEN, D. NEARY, and D. M. A. MANN Frontotemporal dementia The British Journal of Psychiatry, February 1, 2002; 180(2): 140 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R. Morris, M. N. Khan, J. C. Janssen, J. M. Brown, J. Perez-Tur, M. Baker, M. Ozansoy, J. Hardy, M. Hutton, N. W. Wood, et al. The Genetic and Pathological Classification of Familial Frontotemporal Dementia Arch Neurol, November 1, 2001; 58(11): 1813 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Hosler, T. Siddique, P. C. Sapp, W. Sailor, M. C. Huang, A. Hossain, J. R. Daube, M. Nance, C. Fan, J. Kaplan, et al. Linkage of Familial Amyotrophic Lateral Sclerosis With Frontotemporal Dementia to Chromosome 9q21-q22 JAMA, October 4, 2000; 284(13): 1664 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Heutink Untangling tau-related dementia Hum. Mol. Genet., April 1, 2000; 9(6): 979 - 986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Chow, B. L. Miller, V. N. Hayashi, and D. H. Geschwind Inheritance of Frontotemporal Dementia Arch Neurol, July 1, 1999; 56(7): 817 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hardy and K. Gwinn-Hardy Genetic Classification of Primary Neurodegenerative Disease Science, November 6, 1998; 282(5391): 1075 - 1079. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. Bulle, N. Chiannilkulchai, A. Pawlak, J. Weissenbach, G. Gyapay, and G. Guellaen Identification and Chromosomal Localization of Human Genes Containing CAG/CTG Repeats Expressed in Testis and Brain Genome Res., July 1, 1997; 7(7): 705 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Basun, O. Almkvist, K. Axelman, A. Brun, T. A. Campbell, J. Collinge, C. Forsell, S. Froelich, L.-O. Wahlund, L. Wetterberg, et al. Clinical Characteristics of a Chromosome 17--Linked Rapidly Progressive Familial Frontotemporal Dementia Arch Neurol, May 1, 1997; 54(5): 539 - 544. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Kobuke, Y. Furukawa, M. Sugai, K. Tanigaki, N. Ohashi, A. Matsumori, S. Sasayama, T. Honjo, and K. Tashiro ESDN, a Novel Neuropilin-like Membrane Protein Cloned from Vascular Cells with the Longest Secretory Signal Sequence among Eukaryotes, Is Up-regulated after Vascular Injury J. Biol. Chem., August 31, 2001; 276(36): 34105 - 34114. [Abstract] [Full Text] [PDF]
|
|