Human Molecular Genetics, Vol 5, 1649-1655, Copyright © 1996 by Oxford University Press
R Allikmets, B Gerrard, A Hutchinson and M Dean
As an approach to characterizing all human ATP-binding cassette (ABC)
superfamily genes, a search of the human expressed sequence tag (EST)
database was performed using sequences from known ABC genes. A total of 105
clones, containing sequences of potential ABC genes, were identified,
representing 21 distinct genes. This brings the total number of
characterized human ABC genes from 12 to 33. The new ABC genes were mapped
by PCR on somatic cell and radiation hybrid panels and yeast artificial
chromosomes (YACs). The genes are located on human chromosomes 1, 2, 3, 4,
6, 7, 10, 12, 13, 14, 16, 17 and X; at locations distinct from previously
mapped members of the superfamily. The characterized genes display
extensive diversity in sequence and expression pattern and this information
was utilized to determine potential structural, functional and evolutionary
relationships to previously characterized members of the ABC superfamily.
ARTICLES
Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database
Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702, USA.
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J. Wijnholds, C. A. A. M. Mol, L. van Deemter, M. de Haas, G. L. Scheffer, F. Baas, J. H. Beijnen, R. J. Scheper, S. Hatse, E. De Clercq, et al. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs PNAS, June 20, 2000; 97(13): 7476 - 7481. [Abstract] [Full Text] [PDF]
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