Human Molecular Genetics, Vol 5, 1679-1683, Copyright © 1996 by Oxford University Press
JD Ohmen, HY Yang, KK Yamamoto, HY Zhao, Y Ma, LG Bentley, Z Huang, S Gerwehr, S Pressman, C McElree, S Targan, JI Rotter and N Fischel-Ghodsian
In the Western world, chronic inflammatory bowel disease (IBD) presents as
two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC)
[Targan, S.R. and Shanahan, F. (1994). In Retford, D.C (ed.), Inflammatory
Bowel Disease: From Bench to Bedside. Williams and Wilkins, Baltimore].
Genetic epidemiological studies, the occurrence of rare syndromes
associated with IBD, and animal models suggest that inherited factors play
significant roles in the susceptibility to both forms of IBD [Yang, H.-Y.
and Rotter, J.I. (1995) In Kirsner, J.B. and Shorter, R.G. (eds). Genetic
Aspects of Idiopathic Inflammatory Bowel Disease. Williams and Wilkins,
Baltimore, pp.301-331]. Recently, a genome-wide search on European families
with multiple affected members with CD identified a putative susceptibility
locus in the centromeric region of chromosome 16 [Hugot, J.-P. et al.
(1996) Nature, 379, 821- 823]. We have now tested this region in an
independent set of US families, confirmed that this region is likely to
contain a gene predisposing to CD, and further refined the chromosomal
location of this gene. Most importantly with respect to this locus, our
data also seem to indicate that there is heterogeneity both within the CD
group, and between the CD and UC groups with respect to this locus. The
susceptibility locus appears to be involved only in non-Jewish CD sibpairs
and not in our Ashkenazi Jewish CD sibpairs. Additionally, we have tested
sibpairs having either only UC or both UC and CD for involvement of this
locus, and have found no evidence that this region predisposes to IBD in
these patients.
ARTICLES
Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis
GenoMed Pharmaceuticals, Inc., Beverly Hills CA 90211, USA.
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