Human Molecular Genetics, Vol 5, 2005-2011, Copyright © 1996 by Oxford University Press
Z Shan, P Hirschmann, T Seebacher, A Edelmann, A Jauch, J Morell, P Urbitsch and PH Vogt
We have isolated a series of human testis poly(A) cDNA clones by cross-
hybridization to SPGY1, a Y gene homologous to DAZ. Their sequence analysis
revealed an identical nucleotide composition in different 'full-length'
clones, suggesting that all were encoded by the same gene. We mapped this
gene to the short arm of chromosome 3 and designated it SPGYLA (SPGY like
autosomal). Comparison of the SPGYLA cDNA sequence with the cDNA sequences
of DAZ and SPGY1 revealed two prominent differences. The tandem repetitive
structure of 72 bp sequence units (DAZ repeats) is absent. SPGYLA contains
only one 72 bp sequence unit. Downstream of it, a specific 130 bp sequence
domain is present which is absent in DAZ and SPGY1 but present in the mouse
gene Dazla and in the Drosophila gene boule. SPGYLA encodes an RNA binding
protein expressed only in the human male gonad. The data presented give
strong evidence that not DAZ but SPGYLA is the functional human homologue
of Dazla and boule.
ARTICLES
A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad
Institute of Human Genetics, University of Heidelberg, Germany.
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