Human Molecular Genetics, Vol 5, 513-516, Copyright © 1996 by Oxford University Press
HJ Cooke, M Lee, S Kerr and M Ruggiu
We have isolated a homologue of the human Y linked DAZ (deleted in
azoospermia) gene from mouse. This gene, Dazla (Daz like, autosomal), is
autosomal, located on chromosome 17 and apparently single copy. The
predicted protein is highly homologous to that encoded by the DAZ gene in
the N-terminal regions of the two proteins and this homology is not
confined to the RNA binding domain. Analysis of its expression pattern by
reverse transcription PCR shows that the transcript is only detectable in
male and female gonads and that testes lacking germ cells do not contain
detectable amounts of transcript. We have been unable to detect a Y-linked
DAZ homologue in mouse and our results point to the possibility of a role
for autosomal RNA binding proteins in mammalian gametogenesis.
ARTICLES
A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK.
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