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Human Molecular Genetics, Vol 5, 675-684, Copyright © 1996 by Oxford University Press

ARTICLES

A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region

AM Theodosiou, NR Rodrigues, MA Nesbit, HJ Ambrose, H Paterson, E McLellan- Arnold, Y Boyd, MA Leversha, N Owen, DJ Blake, A Ashworth and KE Davies
Biochemistry Department, University of Oxford, UK.

We have identified a novel mouse gene encoding a protein that shows high homology to the dual-specificity tyrosine/threonine phosphatase family of proteins. The gene encodes a 5 kb transcript which is expressed predominantly in brain and lung and contains a translated complex trinucleotide repeat within the coding region. Using interspecific mouse backcross analysis, the gene has been localised to distal mouse chromosome 7. In human, homologous sequences are located in the syntenic region on distal chromosome 11p as well as to chromosome 10q11.2 and 10q22. The presence of a CG-rich trinucleotide repeat in the coding region provides a target for mutation which might result in loss of function or altered properties of this phosphatase.
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