Human Molecular Genetics, Vol 5, 685-691, Copyright © 1996 by Oxford University Press
PM Lansdorp, NP Verwoerd, FM van de Rijke, V Dragowska, MT Little, RW Dirks, AK Raap and HJ Tanke
Vertebrate chromosomes terminate in variable numbers of T2AG3 nucleotide
repeats. In order to study telomere repeats at individual chromosomes, we
developed novel, quantitative fluorescence in situ hybridization procedures
using labeled (C3TA2)3 peptide nucleic acid and digital imaging microscopy.
Telomere fluorescence intensity values from metaphase chromosomes of
cultured human hematopoietic cells decreased with the replication history
of the cells, varied up to six- fold within a metaphase, and were similar
between sister chromatid telomeres. Surprisingly, telomere fluorescence
intensity values within normal adult bone marrow metaphases did not show a
normal distribution, suggesting that a minimum number of repeats at each
telomere is required and/or maintained during normal hematopoiesis.
ARTICLES
Heterogeneity in telomere length of human chromosomes
Terry Fox Laboratory, B.C. Cancer Agency, Vancouver, Canada.
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K. S. Hathcock, M. T. Hemann, K. K. Opperman, M. A. Strong, C. W. Greider, and R. J. Hodes Haploinsufficiency of mTR results in defects in telomere elongation PNAS, March 19, 2002; 99(6): 3591 - 3596. [Abstract] [Full Text] [PDF]
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Y. Liu, H. Kha, M. Ungrin, M. O. Robinson, and L. Harrington Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert PNAS, March 19, 2002; 99(6): 3597 - 3602. [Abstract] [Full Text] [PDF]
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J. F. Riou, L. Guittat, P. Mailliet, A. Laoui, E. Renou, O. Petitgenet, F. Megnin-Chanet, C. Helene, and J. L. Mergny Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands PNAS, February 14, 2002; (2002) 52698099. [Abstract] [Full Text] [PDF]
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D. Gisselsson, T. Jonson, A. Petersen, B. Strombeck, P. Dal Cin, M. Hoglund, F. Mitelman, F. Mertens, and N. Mandahl Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors PNAS, September 26, 2001; (2001) 211357798. [Abstract] [Full Text] [PDF]
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J. A. Londono-Vallejo, H. DerSarkissian, L. Cazes, and G. Thomas Differences in telomere length between homologous chromosomes in humans Nucleic Acids Res., August 1, 2001; 29(15): 3164 - 3171. [Abstract] [Full Text] [PDF]
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M. T. Hemann, K. L. Rudolph, M. A. Strong, R. A. DePinho, L. Chin, and C. W. Greider Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis Mol. Biol. Cell, July 1, 2001; 12(7): 2023 - 2030. [Abstract] [Full Text] [PDF]
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K. Perrem, L. M. Colgin, A. A. Neumann, T. R. Yeager, and R. R. Reddel Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells Mol. Cell. Biol., June 15, 2001; 21(12): 3862 - 3875. [Abstract] [Full Text]
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F. A. Goytisolo, E. Samper, S. Edmonson, G. E. Taccioli, and M. A. Blasco The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang Mol. Cell. Biol., June 1, 2001; 21(11): 3642 - 3651. [Abstract] [Full Text]
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R. C. Allsopp, S. Cheshier, and I. L. Weissman Telomere Shortening Accompanies Increased Cell Cycle Activity during Serial Transplantation of Hematopoietic Stem Cells J. Exp. Med., April 16, 2001; 193(8): 917 - 924. [Abstract] [Full Text] [PDF]
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J. W. Shay, Y. Zou, E. Hiyama, and W. E. Wright Telomerase and cancer Hum. Mol. Genet., April 1, 2001; 10(7): 677 - 685. [Abstract] [Full Text] [PDF]
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M. Fenton, S. Barker, D. J. Kurz, and J. D. Erusalimsky Cellular Senescence After Single and Repeated Balloon Catheter Denudations of Rabbit Carotid Arteries Arterioscler Thromb Vasc Biol, February 1, 2001; 21(2): 220 - 226. [Abstract] [Full Text] [PDF]
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R. Nagele, A. Velasco, W. Anderson, D. McMahon, Z Thomson, J Fazekas, K Wind, and H Lee Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology J. Cell Sci., January 1, 2001; 114(2): 377 - 388. [Abstract] [PDF]
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M. T. Hemann and C. W. Greider Wild-derived inbred mouse strains have short telomeres Nucleic Acids Res., November 15, 2000; 28(22): 4474 - 4478. [Abstract] [Full Text] [PDF]
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T. A. Ebersole, A. Ross, E. Clark, N. McGill, D. Schindelhauer, H. Cooke, and B. Grimes Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats Hum. Mol. Genet., July 1, 2000; 9(11): 1623 - 1631. [Abstract] [Full Text] [PDF]
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H. Niida, Y. Shinkai, M. P. Hande, T. Matsumoto, S. Takehara, M. Tachibana, M. Oshimura, P. M. Lansdorp, and Y. Furuichi Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA Mol. Cell. Biol., June 1, 2000; 20(11): 4115 - 4127. [Abstract] [Full Text]
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 A. RAY and B. NORDÉN Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future FASEB J, June 1, 2000; 14(9): 1041 - 1060. [Abstract] [Full Text]
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R. Figueroa, H. Lindenmaier, M. Hergenhahn, K. V. Nielsen, and P. Boukamp Telomere Erosion Varies during in Vitro Aging of Normal Human Fibroblasts from Young and Adult Donors Cancer Res., June 1, 2000; 60(11): 2770 - 2774. [Abstract] [Full Text] [PDF]
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A. Smogorzewska, B. van Steensel, A. Bianchi, S. Oelmann, M. R. Schaefer, G. Schnapp, and T. de Lange Control of Human Telomere Length by TRF1 and TRF2 Mol. Cell. Biol., March 1, 2000; 20(5): 1659 - 1668. [Abstract] [Full Text]
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 V Uhlmann, M Prasad, I Silva, K Luettich, L Grande, L Alonso, M Thisted, K J Pluzek, J Gorst, M Ring, et al. Improved in situ detection method for telomeric tandem repeats in metaphase spreads and interphase nuclei Mol. Pathol., February 1, 2000; 53(1): 48 - 50. [Abstract] [Full Text]
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E.H. BLACKBURN, S. CHAN, J. CHANG, T.B. FULTON, A. KRAUSKOPF, M. MCEACHERN, J. PRESCOTT, J. ROY, C. SMITH, and H. WANG Molecular Manifestations and Molecular Determinants of Telomere Capping Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 253 - 264. [Abstract] [PDF]
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K. Weipoltshammer, C. Schofer, M. Almeder, V. V. Philimonenko, K. Frei, F. Wachtler, and P. Hozak Intranuclear Anchoring of Repetitive DNA Sequences: Centromeres, Telomeres, and Ribosomal DNA J. Cell Biol., December 27, 1999; 147(7): 1409 - 1418. [Abstract] [Full Text] [PDF]
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