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Human Molecular Genetics, Vol 5, 853-856, Copyright © 1996 by Oxford University Press

ARTICLES

A gene for autosomal dominant late-onset progressive non-syndromic hearing loss, DFNA10, maps to chromosome 6

ME O'Neill, J Marietta, D Nishimura, S Wayne, G Van Camp, L Van Laer, C Negrini, ER Wilcox, A Chen, K Fukushima, L Ni, VC Sheffield and RJ Smith
Department of Otolaryngology, University of Iowa, Iowa City 52242, USA.

Late-onset non-syndromic hearing impairment is the most common type of neurological dysfunction in the elderly. It can be either acquired or inherited, although the relative impact of heredity on this type of loss is not known. To date, nine different genes have been localized, but none has been cloned. Using an extended American family in which a gene for autosomal dominant late-onset non-syndromic hearing impairment is segregating, we have identified a new locus, DFNA10, on chromosome 6.
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