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Human Molecular Genetics, Vol 5, 1123-1127, Copyright © 1996 by Oxford University Press

ARTICLES

Biallelic expression of the IGF2 gene in human breast disease

AH McCann, N Miller, A O'Meara, I Pedersen, K Keogh, T Gorey and PA Dervan
Department of Pathology, University College Dublin (UCD), Belfield, Ireland.

We examined the imprinting status of the insulin-like growth factor II gene (IGF2) in a series of 20 human breast disease samples to determine if disrupted imprinting (as evidenced by biallelic expression), was a demonstrable mechanism of altered gene expression. These samples included benign (n = 7) and malignant breast lesions (n = 13). Biallelic expression of IGF2 was detectable in 67% of benign and 60% of malignant informative breast lesions. Three informative reduction mastectomies displayed normal IGF2 imprinting. The presence of this alteration in human breast tissue is a novel finding, and may contribute to tumorigenesis, possibly by favouring an enhanced proliferative milieu, during which additional mutations could occur.
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