Human Molecular Genetics, Vol 5, 1129-1130, Copyright © 1996 by Oxford University Press
T Shirakawa, XQ Mao, S Sasaki, T Enomoto, M Kawai, K Morimoto and J Hopkin
A genetic association study was performed with coding variants of Fc
epsilon RI beta in relation to atopic and non-atopic asthma in a Japanese
population (n = 400). A coding variant of Gly237Glu in exon 7 of Fc epsilon
RI beta gene showed association with atopic asthma (OR = 3.00, chi 2 =
5.10, p < 0.03), but not with non-atopic asthma; this was seen
particularly in childhood asthma (OR = 3.92, chi 2 = 8.66, p < 0.005).
This variant is also associated with very high total serum IgE levels (>
mean + 3 SD, OR = 8.56, chi 2 = 46.2, p < 0.0001), but not any allergen
specific IgE. However, Leu181lle, another variant of Fc epsilon RI beta
related to atopy in British and Australian populations, was not found in
this Japanese population. These results suggest that variants of Fc epsilon
RI beta may be an important genetic cause of the atopic asthma.
ARTICLES
Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population [published erratum appears in Hum Mol Genet 1996 Dec;5(12):2068]
Osler Chest Unit, Churchill Hospital, Oxford, UK.
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