Human Molecular Genetics, Vol 5, 1361-1366, Copyright © 1996 by Oxford University Press
L Carrel, PA Hunt and HF Willard
To understand how gene expression patterns are established on the inactive
X chromosome during development, we have studied the murine gene Smcx,
which is expressed from both the active and inactive mouse X chromosomes.
In all tissues assayed, Smcx only partially escapes X inactivation, with
expression levels from the inactive X allele approximately 30-65% that of
the active X allele. Additionally, inactive X expression levels differed
between extraembryonic and embryonic tissues and among different tissues
from newborn and adult mice. Imprinted extraembryonic tissue had the lowest
levels of inactive X Smcx expression, whereas the highest levels were in
heart. These data suggest that the chromosomal basis of X inactivation
differs among tissues, perhaps reflecting differences in the timing or
regulation of inactivation in these cell lineages.
ARTICLES
Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Li and L. Carrel Escape from X chromosome inactivation is an intrinsic property of the Jarid1c locus PNAS, November 4, 2008; 105(44): 17055 - 17060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-G. Jeon, G. Coppola, S. D Perrault, G.-J. Rho, D. H Betts, and W A. King S-adenosylhomocysteine treatment of adult female fibroblasts alters X-chromosome inactivation and improves in vitro embryo development after somatic cell nuclear transfer Reproduction, June 1, 2008; 135(6): 815 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Wang, D. C. Page, and J. R. McCarrey Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse Hum. Mol. Genet., October 1, 2005; 14(19): 2911 - 2918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Cordes N-Ethyl-N-Nitrosourea Mutagenesis: Boarding the Mouse Mutant Express Microbiol. Mol. Biol. Rev., September 1, 2005; 69(3): 426 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gomez and N. Brockdorff Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage PNAS, May 4, 2004; 101(18): 6923 - 6928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Chowers, D. Liu, R. H. Farkas, T. L. Gunatilaka, A. S. Hackam, S. L. Bernstein, P. A. Campochiaro, G. Parmigiani, and D. J. Zack Gene expression variation in the adult human retina Hum. Mol. Genet., November 15, 2003; 12(22): 2881 - 2893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Carrel and H. F. Willard Heterogeneous gene expression from the inactive X chromosome: An X-linked gene that escapes X inactivation in some human cell lines but is inactivated in others PNAS, June 22, 1999; 96(13): 7364 - 7369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Miller and H. F. Willard Chromosomal basis of X chromosome inactivation: Identification of a multigene domain in Xp11.21-p11.22 that escapes X inactivation PNAS, July 21, 1998; 95(15): 8709 - 8714. [Abstract] [Full Text] [PDF]
|
|