Human Molecular Genetics, Vol 5, 1405-1410, Copyright © 1996 by Oxford University Press
E Boerwinkle, DL Ellsworth, DM Hallman and A Biddinger
Rapid discoveries of novel and unexpected disease-associated genes for
atherosclerotic coronary artery disease (CAD) are anticipated as genomic
maps become more detailed and methods for mapping complex disease
phenotypes become more refined. Although establishing association or
linkage of a marker locus to a CAD susceptibility gene is an important
first step, the long-term goal should be to define the underlying
functional mutations and explore possible disease mechanisms, including the
gene-environment interactions that culminate in clinically apparent
disease. This review will define a contemporary research paradigm for study
of the genetics of CAD and other common chronic diseases using the tools of
modern molecular biology and human genetics.
REVIEWS
Genetic analysis of atherosclerosis: a research paradigm for the common chronic diseases
Human Genetics Center, University of Texas-Houston Health Science Center, Houston 77225, USA.
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