Human Molecular Genetics, Vol 5, 1471-1488, Copyright © 1996 by Oxford University Press
C Freund, DJ Horsford and RR McInnes
We review the current knowledge of transcription factors in mammallan eye
development. The 14 transcription factors presently known to be required
for eye formation are examined in some detail, incorporating data from both
humans and rodents. Aspects of the biochemistry, expression patterns,
genetics, mutant phenotypes, and biological insights acquired from the
examination of loss-of-function mutations are summarized. The other 32
tissue-restricted transcription factors that are currently known to be
expressed in the developing or mature mammallan eye are tabulated, together
with the timing and site of their ocular expression; the requirement for
most of these genes in the eye is unknown. Contributions to mammallan eye
development from the study of the genetics of the Drosophila eye are
discussed briefly. Identification of the entire cohort of transcription
factors required for eye development is an essential first step towards
understanding the mechanisms underlying eye morphogenesis and
differentiation, and the molecular basis of inherited eye abnormalities in
humans.
REVIEWS
Transcription factor genes and the developing eye: a genetic perspective
Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada.
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