Human Molecular Genetics, Vol 6, 1755-1760, Copyright © 1997 by Oxford University Press
PW Ingham
The identification of genes via their mutant phenotypes is the most direct
way of dissecting the molecular basis of developmental processes. While
this approach has been extremely powerful in invertebrates such as
Drosophila and Caenorhabditis elegans, it has until recently been lacking
in vertebrates. Now two landmark studies by the groups of Nusslein-Volhard
and Driever have for the first time provided the basis for a comprehensive
genetic dissection of vertebrate development using the teleost fish, Danio
rerio. The mutations identified in these screens look set to revolutionise
our understanding of vertebrate development.
REVIEWS
Zebrafish genetics and its implications for understanding vertebrate development
Developmental Genetics Programme, The Krebs Institute, University of Sheffield, UK. p.w.ingham@sheffield.ac.uk
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