Human Molecular Genetics, Vol 6, 1817-1822, Copyright © 1997 by Oxford University Press
U Fischer, D Heckel, A Michel, M Janka, T Hulsebos and E Meese
Gene amplification, which is generally considered to occur late in tumor
development, is a common feature of high grade glioma. Up until now, there
have been no reports on amplification in astrocytoma grade I. In this
study, we report cloning and sequencing of a cDNA termed glioma-amplified
sequence (GAS41) which was identified recently in a glioblastoma cell line
by microdissection-mediated cDNA capture. This technique is tailored to
isolate amplified genes from human tumors. An increased copy number of
GAS41 was found in glioblastoma multiforme and astrocytoma III, and at a
high frequency in astrocytoma grades I and II. Sequence comparison
indicates a high homology between the GAS41 protein, the yeast and human
AF-9 and the human ENL proteins. Both AF-9 and ENL belong to a new class of
transcription factors, indicating that GAS41 might also represent a
transcription factor. With GAS41 being the first gene found with increased
copy number in low grade glioma, this study provides the first evidence
that gene amplification can occur in early tumor development.
ARTICLES
Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I
Department of Human Genetics, Medical School, University Hospital, Homburg/Saar, Germany.
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