Human Molecular Genetics, Vol 6, 1887-1889, Copyright © 1997 by Oxford University Press
C Bouchard, L Perusse, YC Chagnon, C Warden and D Ricquier
The recent cloning of a gene that codes for a novel uncoupling protein,
UCP2, which is expressed in a wide range of adult human tissues, has raised
the possibility that it may be involved in regulation of energy balance. To
explore this concept we have investigated potential linkage relationships
between three microsatellite markers which encompass the UCP2 gene location
on 11q13 with resting metabolic rate (RMR), body mass index, percentage
body fat (%FAT) and fat mass (FM) in 640 individuals from 155 pedigrees
from the Quebec Family Study. Using a linkage analysis strategy based on
sibling, avuncular, grandparental and cousin pairs, strong evidence of
linkage was found between the marker D11S911 (P = 0.000002) and RMR, with
more moderate evidence for D11S916 (P = 0.006) and D11S1321 (P = 0.02).
Suggestive evidence of linkage was also observed between D11S1321 and %FAT
(P = 0.04) and FM (P = 0.02). It is concluded that the three markers
encompassing the UCP2 locus and spanning a 5 cM region on 11q13 are linked
to resting energy expenditure in adult humans. The evidence is strong
enough to warrant a search for DNA sequence variation in the gene itself.
ARTICLES
Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Quebec, Canada. claude.bouchard@kin.msp.ulaval.ca
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