Human Molecular Genetics, Vol 6, 1951-1959, Copyright © 1997 by Oxford University Press
GA Carlson, DR Borchelt, A Dake, S Turner, V Danielson, JD Coffin, C Eckman, J Meiners, SP Nilsen, SG Younkin and KK Hsiao
Overexpression of Alzheimer amyloid precursor protein (APP) produces
dramatically different phenotypes in transgenic mice depending on the
genetic background. For example, concentrations of APP that produce amyloid
plaques in outbred transgenic lines are lethal for inbred FVB/N or C57BL/6J
mice. Expression of SOD1 transgenes is protective, suggesting involvement
of oxidative damage in premature death, but ablation of Apoe had no
significant effect. In contrast, FGF2 transgene overexpression enhances the
lethal effects of APP. Differential survival does not appear to reflect
genetic differences in APP processing, but rather host responses to APP or
its derivatives.
ARTICLES
Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice
McLaughlin Research Institute, Great Falls, MT 59405, USA. gac@po.mri.montana.edu
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Freude, M. M. Hettich, C. Schumann, O. Stohr, L. Koch, C. Kohler, M. Udelhoven, U. Leeser, M. Muller, N. Kubota, et al. Neuronal IGF-1 resistance reduces A{beta} accumulation and protects against premature death in a model of Alzheimer's disease FASEB J, October 1, 2009; 23(10): 3315 - 3324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Ehrnhoefer, S. L. Butland, M. A. Pouladi, and M. R. Hayden Mouse models of Huntington disease: variations on a theme Dis. Model. Mech., March 1, 2009; 2(3-4): 123 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sebastiani, P. Krzywkowski, S. Dudal, M. Yu, J. Paquette, D. Malo, F. Gervais, and P. Tremblay Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice Hum. Mol. Genet., August 1, 2006; 15(15): 2313 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Krezowski, D. Knudson, C. Ebeling, R. Pitstick, R. K. Giri, D. Schenk, D. Westaway, L. Younkin, S. G. Younkin, K. H. Ashe, et al. Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression Hum. Mol. Genet., September 15, 2004; 13(18): 1989 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chin, J. J. Palop, G.-Q. Yu, N. Kojima, E. Masliah, and L. Mucke Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice J. Neurosci., May 12, 2004; 24(19): 4692 - 4697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Li, D. Cao, D. W. Garber, H. Kim, and K.-i. Fukuchi Association of Aortic Atherosclerosis with Cerebral {beta}-Amyloidosis and Learning Deficits in a Mouse Model of Alzheimer's Disease Am. J. Pathol., December 1, 2003; 163(6): 2155 - 2164. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. A. Bayer, S. Schafer, A. Simons, A. Kemmling, T. Kamer, R. Tepest, A. Eckert, K. Schussel, O. Eikenberg, C. Sturchler-Pierrat, et al. Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid A{beta} production in APP23 transgenic mice PNAS, November 25, 2003; 100(24): 14187 - 14192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Phinney, B. Drisaldi, S. D. Schmidt, S. Lugowski, V. Coronado, Y. Liang, P. Horne, J. Yang, J. Sekoulidis, J. Coomaraswamy, et al. In vivo reduction of amyloid-{beta} by a mutant copper transporter PNAS, November 25, 2003; 100(24): 14193 - 14198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J.H. Lehman, L. S. Kulnane, Y. Gao, M. C. Petriello, K. M. Pimpis, L. Younkin, G. Dolios, R. Wang, S. G. Younkin, and B. T. Lamb Genetic background regulates {beta}-amyloid precursor protein processing and {beta}-amyloid deposition in the mouse Hum. Mol. Genet., November 15, 2003; 12(22): 2949 - 2956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Sousa, R. Fernandes, J. A. Palha, A. Taboada, P. Vieira, and M. J. Saraiva Evidence for Early Cytotoxic Aggregates in Transgenic Mice for Human Transthyretin Leu55Pro Am. J. Pathol., November 1, 2002; 161(5): 1935 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lorenzetti, K. Watase, B. Xu, M. M. Matzuk, H. T. Orr, and H. Y. Zoghbi Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Sca1 locus Hum. Mol. Genet., March 22, 2000; 9(5): 779 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Yan, A. Roher, A. M. Schmidt, and D. M. Stern Cellular Cofactors for Amyloid {beta}-Peptide-Induced Cell Stress : Moving from Cell Culture to in Vivo Am. J. Pathol., November 1, 1999; 155(5): 1403 - 1411. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Moechars, I. Dewachter, K. Lorent, D. Reverse, V. Baekelandt, A. Naidu, I. Tesseur, K. Spittaels, C. V. D. Haute, F. Checler, et al. Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain J. Biol. Chem., March 5, 1999; 274(10): 6483 - 6492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Askanas and W. K. Engel Does Overexpression of ßAPP in Aging Muscle Have a Pathogenic Role and a Relevance to Alzheimer's Disease? : Clues from Inclusion Body Myositis, Cultured Human Muscle, and Transgenic Mice Am. J. Pathol., December 1, 1998; 153(6): 1673 - 1677. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Chishti, D.-S. Yang, C. Janus, A. L. Phinney, P. Horne, J. Pearson, R. Strome, N. Zuker, J. Loukides, J. French, et al. Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695 J. Biol. Chem., June 8, 2001; 276(24): 21562 - 21570. [Abstract] [Full Text] [PDF]
|
|