Human Molecular Genetics, Vol 6, 2021-2029, Copyright © 1997 by Oxford University Press
N Qian, D Frank, D O'Keefe, D Dao, L Zhao, L Yuan, Q Wang, M Keating, C Walsh and B Tycko
We searched for novel imprinted genes in a region of human chromosome
11p15.5, which contains several known imprinted genes. Here we describe the
cloning and characterization of the IPL ( I mprinted in P lacenta and L
iver) gene, which shows tissue-specific expression and functional
imprinting, with the maternal allele active and the paternal allele
relatively inactive, in many human and mouse tissues. Human IPL is highly
expressed in placenta and shows low but detectable expression in fetal and
adult liver and lung. Mouse Ipl maps to the region of chromosome 7 which is
syntenic with human 11p15.5 and this gene is expressed in placenta and at
higher levels in extraembryonic membranes (yolk sac), fetal liver and adult
kidney. Mouse and human IPL show sequence similarity to TDAG51 , a gene
which was shown to be essential for Fas expression and susceptibility to
apoptosis in a T lymphocyte cell line. Like several other imprinted genes,
mouse and human IPL genes are small and contain small introns. These data
expand the repertoire of known imprinted genes and will be helpful in
testing the mechanism of genomic imprinting and the role of imprinted genes
in growth regulation.
ARTICLES
The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
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