Human Molecular Genetics, Vol 6, 2151-2154, Copyright © 1997 by Oxford University Press
JC Lambert, J Perez-Tur, MJ Dupire, D Galasko, D Mann, P Amouyel, J Hardy, A Delacourte and MC Chartier-Harlin
The APOE epsilon4 allele is a strong genetic susceptibility factor for
Alzheimer's disease. Interaction with other biological factors may modulate
the effect of the apoE isoforms. However, previous work suggested that
other genetic variability within the APOE locus, influencing the effect of
the epsilon4 allele, may exist. Such variability could modify the
expression of the APOE gene and, in particular, the level of expression of
APOE alleles could be an important determinant of disease pathogenesis. To
test this hypothesis we examined the levels of expression of APOE in
heterozygotes with AD and in controls, using a new method of
semi-quantitation. We report that relative epsilon4 mRNA expression is
increased in AD compared with controls and suggest that genetic variability
in the neural expression of APOE contributes to disease risk.
ARTICLES
Distortion of allelic expression of apolipoprotein E in Alzheimer's disease
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