Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (138)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Klauck, S. M.
Right arrow Articles by Poustka, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klauck, S. M.
Right arrow Articles by Poustka, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, Vol 6, 2233-2238, Copyright © 1997 by Oxford University Press

ARTICLES

Serotonin transporter (5-HTT) gene variants associated with autism?

SM Klauck, F Poustka, A Benner, KP Lesch and A Poustka
Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. s.klauck@dkfz-heidelberg.de

An association study was performed to elucidate the role of the serotonin transporter (5-HTT) gene as a susceptibility factor for autism as treatment of patients with antidepressant drugs which selectively target 5-HTT reduced autistic or concomitant symptoms, such as repetitive behavior and aggression, and ameliorate language use. Using the transmission/disequilibrium test (TDT) an analysis was done for a common polymorphism in the upstream regulatory region (5-HTTLPR), a VNTR in intron 2 of the gene and a haplotype of both loci in 52 trios fulfilling stringent criteria for autism and an extended group of 65 trios including patients showing no language delay in their first 3 years of life. A higher frequency and preferential transmission of the long allele of the 5-HTTLPR was observed, but the TDT gave a statistically significant value ( P = 0. 032) only for the extended patient group. This result is in contrast to a recent study by a US group presenting preliminary evidence for preferential transmission of the short allele of 5-HTTLPR in 86 trios. Both studies failed to reveal significant linkage disequilibrium between the VNTR in intron 2 of the gene and autism. In our study haplotype analysis of the 5-HTTLPR and the VNTR in intron 2 supplied evidence for an association of 5-HTT and autism in the stringent ( P = 0.069) and extended patient group ( P = 0.049). Overall, we were not able to replicate the findings of the first study on 5-HTT and autism and instead observed a tendency for association of the opposite genetic variant of the gene with the disorder. The implications for genetic variants of the serotonin transporter in the etiology of autism and possible subgroups of patients, therefore, needs clarification in further studies with other and larger patient samples.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Genome ResHome page
I. Iossifov, T. Zheng, M. Baron, T. C. Gilliam, and A. Rzhetsky
Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network
Genome Res., July 1, 2008; 18(7): 1150 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
T. H. Wassink, H. C. Hazlett, E. A. Epping, S. Arndt, S. R. Dager, G. D. Schellenberg, G. Dawson, and J. Piven
Cerebral Cortical Gray Matter Overgrowth and Functional Variation of the Serotonin Transporter Gene in Autism
Arch Gen Psychiatry, June 1, 2007; 64(6): 709 - 717.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. Muhle, S. V. Trentacoste, and I. Rapin
The Genetics of Autism
Pediatrics, May 1, 2004; 113(5): e472 - e486.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
D. L. Murphy, A. Lerner, G. Rudnick, and K.-P. Lesch
Serotonin Transporter: Gene, Genetic Disorders, and Pharmacogenetics
Mol. Interv., April 1, 2004; 4(2): 109 - 123.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
S. Arbelle, J. Benjamin, M. Golin, I. Kremer, R. H. Belmaker, and R. P. Ebstein
Relation of Shyness in Grade School Children to the Genotype for the Long Form of the Serotonin Transporter Promoter Region Polymorphism
Am J Psychiatry, April 1, 2003; 160(4): 671 - 676.
[Abstract] [Full Text] [PDF]

Home page
 Behav Cogn Neurosci RevHome page
L. A. Femia and M. E. Hasselmo
Is autism partly a consolidation disorder?
Behav Cogn Neurosci Rev, December 1, 2002; 1(4): 251 - 263.
[Abstract] [PDF]

Home page
 Epidemiol RevHome page
C. J. Newschaffer, D. Fallin, and N. L. Lee
Heritable and Nonheritable Risk Factors for Autism Spectrum Disorders
Epidemiol. Rev., December 1, 2002; 24(2): 137 - 153.
[Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. A. Lamb, J. Moore, A. Bailey, and A. P. Monaco
Autism: recent molecular genetic advances
Hum. Mol. Genet., April 1, 2000; 9(6): 861 - 868.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
R. L. Margolis, M. G. McInnis, A. Rosenblatt, and C. A. Ross
Trinucleotide Repeat Expansion and Neuropsychiatric Disease
Arch Gen Psychiatry, November 1, 1999; 56(11): 1019 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
S. G. Ryan
Genetic Susceptibility to Neurodevelopmental Disorders
J Child Neurol, March 1, 1999; 14(3): 187 - 195.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.