Human Molecular Genetics, Vol 6, 291-300, Copyright © 1997 by Oxford University Press
F Connor, A Smith, R Wooster, M Stratton, A Dixon, E Campbell, TM Tait, T Freeman and A Ashworth
A proportion of human breast cancers result from an inherited
predisposition to the disease. Mutations in the BRCA2 gene confer a high
risk of breast cancer and are responsible for almost half of these cases.
The recent cloning of the human BRCA2 gene has revealed that it encodes a
large protein having little significant homology to known proteins. Here we
describe the mouse Brca2 gene. The gene maps to mouse chromosome 5,
consistent with its location on human chromosome 13q12. We have sequenced
cDNA for the entire 3329 amino acid Brca2 protein and this has revealed
that, like Brca1, Brca2 is relatively poorly conserved between humans and
mice. Brca2 is transcribed in a diverse range of mouse tissues, and the
pattern of expression is strikingly similar to that of Brca1. Taken
together, our data highlight some intriguing similarities between two genes
involved in inherited breast cancer susceptibility.
ARTICLES
Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene
CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK.
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