Human Molecular Genetics, Vol 6, 651-657, Copyright © 1997 by Oxford University Press
SK Heath, S Carne, C Hoyle, KJ Johnson and DJ Wells
We examined the expression of the murine homologue of myotonic dystrophy
associated homeodomain protein (mDMAHP) using two different strategies. The
first approach, RT-PCR, detected spliced transcripts in a wide range of
embryonic and adult tissues, in a pattern overlapping substantially with
the expression of mDMPK. A second approach, the generation of transgenic
mice expressing the lacZ reporter gene from a 4.3 kb promoter fragment,
also demonstrated expression in a range of tissues with potential links to
the phenotype in myotonic dystrophy. We conclude that murine DMAHP has a
similar pattern of expression to human DMAHP and will serve as a useful
model for functional studies of this gene, although species differences,
such as the reduced CpG island (1.8 kb compared with 3.5 kb) must be
carefully considered.
ARTICLES
Characterisation of expression of mDMAHP, a homeodomain-encoding gene at the murine DM locus
Department of Pharmacology, Charing Cross & Westminster Medical School, London, UK.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. C. Zhu, M. A. Dyer, M. Uchikawa, H. Kondoh, O. V. Lagutin, and G. Oliver Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors Development, March 8, 2003; 129(12): 2835 - 2849. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sato, M. Nakamura, D. H. Cho, S. J. Tapscott, H. Ozaki, and K. Kawakami Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1 Hum. Mol. Genet., May 1, 2002; 11(9): 1045 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. MISTRY, J. R. MOORMAN, S. REDDY, and J. P. MOUNSEY Skeletal muscle Na currents in mice heterozygous for Six5 deficiency Physiol Genomics, August 28, 2001; 6(3): 153 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Harris, C. L. Winchester, and K. J. Johnson Functional analysis of the homeodomain protein SIX5 Nucleic Acids Res., May 1, 2000; 28(9): 1871 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ohto, S. Kamada, K. Tago, S.-I. Tominaga, H. Ozaki, S. Sato, and K. Kawakami Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya Mol. Cell. Biol., October 1, 1999; 19(10): 6815 - 6824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Kobayashi, R Toyama, H Takeda, I. Dawid, and K Kawakami Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish Development, January 8, 1998; 125(15): 2973 - 2982. [Abstract] [PDF]
|
|