Human Molecular Genetics, Vol 6, 813-820, Copyright © 1997 by Oxford University Press
RC Trembath, RL Clough, JL Rosbotham, AB Jones, RD Camp, A Frodsham, J Browne, R Barber, J Terwilliger, GM Lathrop and JN Barker
Psoriasis is a common chronic inflammatory disorder of the skin. To further
understand the pathogenesis of psoriasis we have chosen to investigate the
molecular genetic basis of the disorder. We have used a two-stage approach
to search the human genome for the location of genes conferring
susceptibility to psoriasis, using a total of 106 affected sibling pairs
identified from 68 independent families. As over a third of the extended
kindreds included affected relatives besides siblings, in addition to an
analysis of allele sharing between affected sibling pairs, a novel linkage
strategy was applied that extracts full non- parametric information. Four
principal regions of possible linkage were identified on chromosomes 2, 8,
20 (p <0.005) and markers from the MHC region at 6p21 (p <0.0000006)
for which significant evidence of linkage disequilibrium was also observed
(p <0.00002). Whilst data from limited case control associations exist
to implicate the MHC, the results of this genome wide analysis demonstrate
that, at least in the population studied, a gene or genes located within
the MHC and close to the class 1 HLA loci, represent the major determinant
of the genetic basis of psoriasis.
ARTICLES
Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis
Department of Genetics, University of Leicester, UK. rtrembat@hgmp.mrc.ac.uk
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|
|
|
|
|
|
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|
|
|
|
|
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|
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|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|