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Human Molecular Genetics, Vol 6, 1017-1020, Copyright © 1997 by Oxford University Press

ARTICLES

The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility

B Olives, M Merriman, P Bailly, S Bain, A Barnett, J Todd, JP Cartron and T Merriman
INSERM U76, GIP-INTS, Paris, France.

The Kidd blood group locus encodes a urea transporter which is expressed on human red cells and in the kidney. This gene is located on chromosome 18q12, and evidence for linkage and association with type 1 diabetes mellitus has been reported. To investigate this further, the genetic basis for the blood group Jk(a)/Jk(b) polymorphism was first determined by sequencing reverse-transcribed reticulocyte RNAs from Jk(a+b-) and Jk(a-b+) donors. The Jk(a)/Jk(b) polymorphism was caused by a transition (G838A), resulting in a Asp280Asn amino acid substitution and an MnlI restriction fragment length polymorphism (RFLP). Using the MnlI RFLP, we found that the Jk(a)/Jk(b) polymorphism was not in linkage disequilibrium with type 1 diabetes in 228 multiplex UK and US families tested.
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