Human Molecular Genetics, Vol 6, 1267-1273, Copyright © 1997 by Oxford University Press
P Suvanto, K Wartiovaara, M Lindahl, U Arumae, M Moshnyakov, N Horelli- Kuitunen, MS Airaksinen, A Palotie, H Sariola and M Saarma
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival
factor for central dopaminergic neurons, motor neurons and several other
populations of neurons in the central and peripheral nervous system. GDNF
and its receptor complex of c-RET tyrosine kinase and a
glycosyl-phosphatidylinositol linked protein GDNFR-alpha are of great
interest due to their potential use in the therapy of Parkinson's and
motoneuron diseases. We have cloned the human and rat cDNA sequences of
GDNFR-beta, a new gene encoding for a 464 amino acid long homologue of
GDNFR-alpha, and assign the locus of this new gene to human chromosome
8p21-22 and mouse chromosome 14D3-E1. Similarly to GDNFR-alpha, GDNFR- beta
mediates GDNF-induced Ret autophosphorylation in transfected cells. By
northern hybridisation we show that the transcript level of human
GDNFR-beta mRNA is high in the adult brain, intestine and placenta and in
fetal brain, lung and kidney. Studied by in situ hybridisation, GDNFR-beta
mRNA shows in E17 rat embryo different distribution to that of GDNFR-alpha
mRNA, especially, in adrenal gland, kidney and gut. In the developing
nervous system, GDNFR-beta mRNA expression is restricted to certain
neuronal populations, while GDNFR- alpha mRNA is widely expressed also in
non-neuronal cells. The distinct tissue distribution of GDNFR-beta mRNA and
its ability to mediate GDNF signal in transfected cells suggest a role in
signal transduction of GDNF and, possibly, related neurotrophic factors in
vivo.
ARTICLES
Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha
Institute of Biotechnology, University of Helsinki, Finland. petro.suvanto@helsinki.fi
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Gianino, J. R. Grider, J. Cresswell, H. Enomoto, and R. O. Heuckeroth GDNF availability determines enteric neuron number by controlling precursor proliferation Development, May 15, 2003; 130(10): 2187 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Meng, H. Akutsu, K. Schoene, C. Reifsteck, E. P. Fox, S. Olson, H. Sariola, R. Yanagimachi, and M. Baetscher Transgene Insertion Induced Dominant Male Sterility and Rescue of Male Fertility Using Round Spermatid Injection Biol Reprod, March 1, 2002; 66(3): 726 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Enomoto, P. A. Crawford, A. Gorodinsky, R. O. Heuckeroth, E. M. Johnson Jr., and J. Milbrandt RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons Development, October 15, 2001; 128(20): 3963 - 3974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Andres, A. Forgie, S. Wyatt, Q. Chen, F. J. de Sauvage, and A. M. Davies Multiple effects of artemin on sympathetic neurone generation, survival and growth Development, October 1, 2001; 128(19): 3685 - 3695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. V. Botchkareva, V. A. Botchkarev, P. Welker, M. Airaksinen, W. Roth, P. Suvanto, S. Muller-Rover, I. M. Hadshiew, C. Peters, and R. Paus New Roles for Glial Cell Line-Derived Neurotrophic Factor and Neurturin : Involvement in Hair Cycle Control Am. J. Pathol., March 1, 2000; 156(3): 1041 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Baloh, M. G. Tansey, E. M. Johnson Jr., and J. Milbrandt Functional Mapping of Receptor Specificity Domains of Glial Cell Line-derived Neurotrophic Factor (GDNF) Family Ligands and Production of GFRalpha 1 RET-specific Agonists J. Biol. Chem., February 4, 2000; 275(5): 3412 - 3420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Doxakis, S Wyatt, and A. Davies Depolarisation causes reciprocal changes in GFR(alpha)-1 and GFR(alpha)-2 receptor expression and shifts responsiveness to GDNF and neurturin in developing neurons Development, January 4, 2000; 127(7): 1477 - 1487. [Abstract] [PDF]
|
|
|
|
 |
|
 M. L. Leitner, D. C. Molliver, P. A. Osborne, R. Vejsada, J. P. Golden, P. A. Lampe, A. C. Kato, J. Milbrandt, and E. M. Johnson Jr Analysis of the Retrograde Transport of Glial Cell Line-Derived Neurotrophic Factor (GDNF), Neurturin, and Persephin Suggests That In Vivo Signaling for the GDNF Family is GFRalpha Coreceptor-Specific J. Neurosci., November 1, 1999; 19(21): 9322 - 9331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Trupp, R. Scott, S. R. Whittemore, and C. F. Ibanez Ret-dependent and -independent Mechanisms of Glial Cell Line-derived Neurotrophic Factor Signaling in Neuronal Cells J. Biol. Chem., July 23, 1999; 274(30): 20885 - 20894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schober, R. Hertel, U. Arumae, L. Farkas, J. Jaszai, K. Krieglstein, M. Saarma, and K. Unsicker Glial Cell Line-Derived Neurotrophic Factor Rescues Target-Deprived Sympathetic Spinal Cord Neurons But Requires Transforming Growth Factor-beta as Cofactor In Vivo J. Neurosci., March 15, 1999; 19(6): 2008 - 2015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M Myers, R. Salomon, A. Goessling, A. Pelet, C. Eng, A. von Deimling, S. Lyonnet, and L. M Mulligan Investigation of germline GFRalpha -1 mutations in Hirschsprung disease J. Med. Genet., March 1, 1999; 36(3): 217 - 220. [Abstract] [Full Text]
|
|
|
|
|
|
S Srinivas, Z Wu, C. Chen, V D'Agati, and F Costantini Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development Development, January 4, 1999; 126(7): 1375 - 1386. [Abstract] [PDF]
|
|
|
|
|
|
K Sainio, P Suvanto, J Davies, J Wartiovaara, K Wartiovaara, M Saarma, U Arumae, X Meng, M Lindahl, V Pachnis, et al. Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium Development, January 10, 1997; 124(20): 4077 - 4087. [Abstract] [PDF]
|
|