Human Molecular Genetics, Vol 6, 1305-1313, Copyright © 1997 by Oxford University Press
J Flint, GP Bates, K Clark, A Dorman, D Willingham, BA Roe, G Micklem, DR Higgs and EJ Louis
We have sequenced and compared DNA from the ends of three human
chromosomes: 4p, 16p and 22q. In all cases the pro-terminal regions are
subdivided by degenerate (TTAGGG)n repeats into distal and proximal sub-
domains with entirely different patterns of homology to other chromosome
ends. The distal regions contain numerous, short (<2 kb) segments of
interrupted homology to many other human telomeric regions. The proximal
regions show much longer (approximately 10-40 kb) uninterrupted homology to
a few chromosome ends. A comparison of all yeast subtelomeric regions
indicates that they too are subdivided by degenerate TTAGGG repeats into
distal and proximal sub-domains with similarly different patterns of
identity to other non-homologous chromosome ends. Sequence comparisons
indicate that the distal and proximal sub-domains do not interact with each
other and that they interact quite differently with the corresponding
regions on other, non- homologous, chromosomes. These findings suggest that
the degenerate TTAGGG repeats identify a previously unrecognized,
evolutionarily conserved boundary between remarkably different subtelomeric
domains.
ARTICLES
Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK. jf@worf.molbiol.ox.ac.uk
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