Human Molecular Genetics, Vol 6, 1349-1356, Copyright © 1997 by Oxford University Press
RP Nair, T Henseler, S Jenisch, P Stuart, CK Bichakjian, W Lenk, E Westphal, SW Guo, E Christophers, JJ Voorhees and JT Elder
In a 12.5 cM genome-wide scan for psoriasis susceptibility loci,
recombination-based tests revealed linkage to the HLA region (Zmax = 3.52),
as well as suggestive linkage to two novel regions: chromosome 16q (60-83.1
cM from pter, Zmax = 2.50), and chromosome 20p (7.5-25 cM from pter, Zmax =
2.62). All three regions yielded P values < or = 0.01 by non-parametric
analysis. Recombination-based and allele sharing methods also confirmed a
previous report of a dominant susceptibility locus on distal chromosome 17q
(108.2 cM from pter, Zmax = 2.09, GENEHUNTER P = 0.0056). We could not
confirm a previously reported locus on distal chromosome 4q; however, a
broad region of unclear significance was identified proximal to this
proposed locus (153.6- 178.4 cM from pter, Zmax = 1.01). Taken together
with our recent results demonstrating linkage to HLA-B and -C, this
genome-wide scan identifies a psoriasis susceptibility locus at HLA,
confirms linkage to 17q, and recommends two novel genomic regions for
further scrutiny. One of these regions (16q) overlaps with a
recently-identified susceptibility locus for Crohn's disease. Psoriasis is
much more common in patients with Crohn's disease than in controls,
suggesting that an immunomodulatory locus capable of influencing both
diseases may reside in this region.
ARTICLES
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan
Department of Dermatology, Medical School, University of Michigan, Ann Arbor 48109, USA.
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