Human Molecular Genetics, Vol 7, 2157-2166, Copyright © 1998 by Oxford University Press
DB Stairs, H Perry Gardner, SI Ha, NG Copeland, DJ Gilbert, NA Jenkins and LA Chodosh
Protein kinases frequently play key roles in the normal regulation of
growth and development in eukaryotic organisms. As a consequence, aberrant
expression or mutations in this family of molecules frequently result in
transformation. Previously, we have conducted a screen to identify protein
kinases that are expressed in the mouse during mammary gland development
and in breast cancer cell lines. We now describe the molecular cloning,
characterization and expression of Krct, a novel serine/threonine protein
kinase unrelated to previously defined families of protein kinases. At the
mRNA level, Krct is widely expressed throughout murine development and in
adult tissues. Despite its ubiquitous expression, Krct is expressed
preferentially within specific cellular compartments in multiple tissues,
in particular within the testis and gastrointestinal tract. At the amino
acid level, Krct is most closely related to four previously undescribed
kinases in Saccharomyces cerevisiae, Arabidopsis thaliana and
Caenorhabditis elegans. Together, these kinases appear to define a novel
subfamily of serine/threonine protein kinases. Krct possesses an unusually
long 5'- untranslated region containing multiple upstream initiation codons
and, in this regard, is similar to many proto-oncogenes that regulate
normal growth and differentiation. In addition, Krct is located on mouse
chromosome 11 closely linked to the epidermal growth factor receptor and,
therefore, is likely to be co-amplified in a variety of human tumors.
ARTICLES
Cloning and characterization of Krct, a member of a novel subfamily of serine/threonine kinases
Department of Molecular and Cellular Engineering and Division of Endocrinology, Diabetes and Metabolism, Stellar-Chance Laboratories, Room 309A, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104-6100, USA.
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