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Human Molecular Genetics, Vol 7, 299-305, Copyright © 1998 by Oxford University Press

ARTICLES

The human FXY gene is located within Xp22.3: implications for evolution of the mammalian X chromosome

J Perry, S Feather, A Smith, S Palmer and A Ashworth
CRC Centre for Cell and Molecular Biology and Section of Gene Function and Regulation, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

It has been proposed that the pseudoautosomal region of mammals has evolved by sequential addition of autosomal material onto the X and Y chromosomes followed by movement of the pseudoautosomal boundary to create X-unique regions. We have previously described a gene, Fxy , that spans the pseudoautosomal boundary in mice such that the first three exons of the gene are located on the X chromosome, but the remainder of the gene is located on both X and Y chromosomes. Therefore, this gene might be in a state of transition between pseudoautosomal and X-unique locations. In support of this theory we show here that the human FXY gene is located in Xp22.3 in humans, proximal to the pseudoautosomal boundary.
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