Human Molecular Genetics, Vol 7, 441-448, Copyright © 1998 by Oxford University Press
L Chakrabarti, J Bristulf, GS Foss and KE Davies
The expression of the FRAXE fragile site on the human X chromosome is
associated with the expansion of a CCG repeat at the 5' end of the FMR2
gene. The repeat expansion results in transcriptional silencing of the gene
and this event has been found to be associated with mild mental handicap in
families. We have previously shown that the gene is particularly abundantly
expressed in the hippocampus and amygdala by northern analysis. Here we
demonstrate the expression pattern of the homologous gene in adult mouse
brain and early mouse embryos. High levels of fmr2 mRNA were noted in the
hippocampus, the piriform cortex, Purkinje cells and the cingulate gyrus.
Expression of fmr2 occurs on, or before, day 7 in the embryo and reaches
its highest levels at 10.5- 11.5 days. A more detailed analysis shows that
the fmr2 expression in the embryo at 11 days is more specific and evident
to the roof of the hind brain and the lateral ventricle of the brain. The
coding sequence of the mouse fmr2 gene shows very high conservation with
88% amino acid identity to the human FMR2 sequence.
ARTICLES
Expression of the murine homologue of FMR2 in mouse brain and during development
Genetics Unit, Biochemistry Department, Oxford University, South Parks Road, Oxford, OX1 3QU, UK.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Bitoun, P. L. Oliver, and K. E. Davies The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling Hum. Mol. Genet., January 1, 2007; 16(1): 92 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Urano, M. Endoh, T. Wada, Y. Morikawa, M. Itoh, Y. Kataoka, T. Taki, H. Akazawa, H. Nakajima, I. Komuro, et al. Infertility with Defective Spermiogenesis in Mice Lacking AF5q31, the Target of Chromosomal Translocation in Human Infant Leukemia Mol. Cell. Biol., August 1, 2005; 25(15): 6834 - 6845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Oliver, E. Bitoun, J. Clark, E. L. Jones, and K. E. Davies Mediation of Af4 protein function in the cerebellum by Siah proteins PNAS, October 12, 2004; 101(41): 14901 - 14906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Gu, K. L. McIlwain, E. J. Weeber, T. Yamagata, B. Xu, B. A. Antalffy, C. Reyes, L. Yuva-Paylor, D. Armstrong, H. Zoghbi, et al. Impaired Conditioned Fear and Enhanced Long-Term Potentiation in Fmr2 Knock-Out Mice J. Neurosci., April 1, 2002; 22(7): 2753 - 2763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Cummings and H. Y. Zoghbi Fourteen and counting: unraveling trinucleotide repeat diseases Hum. Mol. Genet., April 1, 2000; 9(6): 909 - 916. [Abstract] [Full Text] [PDF]
|
|