Human Molecular Genetics, Vol 7, 737-742, Copyright © 1998 by Oxford University Press
A Greenfield, L Carrel, D Pennisi, C Philippe, N Quaderi, P Siggers, K Steiner, PP Tam, AP Monaco, HF Willard and P Koopman
We recently have identified a ubiquitously transcribed mouse Y chromosome
gene, Uty , which encodes a tetratricopeptide repeat (TPR) protein. A
peptide derived from the UTY protein confers H-Y antigenicity on male
cells. Here we report the characterization of a widely transcribed X-linked
homologue of Uty , called Utx , which maps to the proximal region of the
mouse X chromosome and which detects a human X-linked homologue at Xp11.2.
Given that Uty is ubiquitously transcribed, we assayed for Utx expression
from the inactive X chromosome (Xi) in mice and found that Utx escapes X
chromosome inactivation. Only Smcx and the pseudoautosomal Sts gene on the
mouse X chromosome have been reported previously to escape inactivation.
The human UTX gene was also found to be expressed from Xi. We discuss the
significance of these data for our understanding of dosage compensation of
X-Y homologous genes in humans and mice.
ARTICLES
The UTX gene escapes X inactivation in mice and humans
Centre for Molecular & Cellular Biology and Department of Anatomical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia. a.greenfield@har.mrc.ac.uk
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