Human Molecular Genetics, Vol 7, 813-822, Copyright © 1998 by Oxford University Press
M Lako, S Lindsay, P Bullen, DI Wilson, SC Robson and T Strachan
Our current knowledge of mammalian forebrain development is meagre. The
comparatively few relevant anatomical landmarks are, however, being
supplemented by gene expression studies which are able to identify subsets
of anatomical structures. We previously described cloning, subchromosomal
localization and preliminary structural characterization of the human WNT8B
gene, the first mammalian Wnt8b gene to be reported. Wnt genes encode
intercellular signalling molecules which play a variety of critical roles
in early development, including, in several cases, a presumed role in brain
development. In the current report we present the full-length cDNA sequence
and genomic organization of the human Wnt8b gene and report studies of
expression of the Wnt8b gene in human and mouse embryos. The human and
mouse expression patterns appeared identical and were restricted to the
developing brain, with the great majority of expression being found in the
developing forebrain. In the latter case expression was confined to the
germinative neuroepithelium of three sharply delimited regions: the
dorsomedial wall of the telencephalic ventricles (which includes the
developing hippocampus), a discrete region of the dorsal thalamus and the
mammillary and retromammillary regions of the posterior hypothalamus.
Expression in the developing hippocampus may suggest a role for WNT8B in
patterning of this region and subchromosomal localization of the human gene
to 10q24 may suggest it as a candidate gene for partial epilepsy in
families where the disease has been linked to markers in this region.
ARTICLES
A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain
Department of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK.
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