Human Molecular Genetics, Vol 7, 933-935, Copyright © 1998 by Oxford University Press
N Brindle, Y Song, E Rogaeva, S Premkumar, G Levesque, G Yu, M Ikeda, M Nishimura, A Paterson, S Sorbi, R Duara, L Farrer and P St George-Hyslop
The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported
to be associated with Alzheimer disease (AD) in carriers of the epsilon4
allele of the apolipoprotein E (APOE) gene. We have re- examined the
frequency of the BCHE-K allele in a large data set of both sporadic and
familial cases of AD disease, and we have also examined the segregation of
three genetic markers on chromosome 3 near BCHE . Our data neither support
an association of BCHE-K with sporadic or familial AD, nor do they suggest
the existence of another gene nearby on chromosome 3 as a common cause of
familial AD.
ARTICLES
Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease
Centre for Research in Neurodegenerative Diseases, Department of Medicine (Division of Neurology), University of Toronto, Toronto, Ontario, Canada.
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