Human Molecular Genetics, Vol 7, 1039-1046, Copyright © 1998 by Oxford University Press
HJ Han, T Tokino and Y Nakamura
Oxidative stress is a pathogenic condition that causes cellular damage and,
in a normally functioning cell, several transcription factors respond to
this threat by modulating expression of genes whose products ameliorate the
altered redox status in some way. We have isolated a novel macrophage
scavenger receptor-like gene, CSR (cellular stress response), whose
transcription in normal fibroblasts was significantly elevated by exposure
to UV radiation or hydrogen peroxide, and pre- treatment with antioxidants
prevented induction of CSR . Under conditions of oxidative stress, reactive
oxygen species were significantly depleted in CSR -overexpressing cells,
indicating that the CSR product protects cells by scavenging oxidative
molecules or harmful products of oxidation. Further investigations into the
regulation and function of CSR should open a way to understanding the
cellular response and the pathogenic processes caused by oxidative stress.
ARTICLES
CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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