Human Molecular Genetics, Vol 7, 1393-1398, Copyright © 1998 by Oxford University Press
C Ober, NJ Cox, M Abney, A Di Rienzo, ES Lander, B Changyaleket, H Gidley, B Kurtz, J Lee, M Nance, A Pettersson, J Prescott, A Richardson, E Schlenker, E Summerhill, S Willadsen and R Parry
Founder populations offer many advantages for mapping genetic traits,
particularly complex traits that are likely to be genetically
heterogeneous. To identify genes that influence asthma and asthma-
associated phenotypes, we conducted a genome-wide screen in the Hutterites,
a religious isolate of European ancestry. A primary sample of 361
individuals and a replication sample of 292 individuals were evaluated for
asthma phenotypes according to a standardized protocol. A genome-wide
screen has been completed using 292 autosomal and three X-Y pseudoautosomal
markers. Using the semi-parametric likelihood ratio chi2 test and the
transmission-disequilibrium test, we identified 12 markers in 10 regions
that showed possible linkage to asthma or an associated phenotype
(likelihood ratio P < 0.01). Markers in four regions (5q23-31,
12q15-24.1, 19q13 and 21q21) showed possible linkage in both the primary
and replication samples and have also shown linkage to asthma phenotypes in
other samples; two adjacent markers in one additional region (3p24.2-22)
showing possible linkage is reported for the first time in the Hutterites.
The results suggest that even in founder populations with a relatively
small number of independent genomes, susceptibility alleles at many loci
may influence asthma phenotypes and that these susceptibility alleles are
likely to be common polymorphisms in the population.
ARTICLES
Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma
Department of Human Genetics, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA. carole@genetics.uchicago.edu
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