Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (72)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Pastinen, T.
Right arrow Articles by Syvanen, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pastinen, T.
Right arrow Articles by Syvanen, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, Vol 7, 1453-1462, Copyright © 1998 by Oxford University Press

ARTICLES

Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population

T Pastinen, M Perola, P Niini, J Terwilliger, V Salomaa, E Vartiainen, L Peltonen and A Syvanen
Department of Human Molecular Genetics, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland. tomi.pastinen@ktl.fi

We analysed common variants of eight genes implicated previously as risk factors for coronary heart disease or myocardial infarction (MI) in a cross-sectional study on patients with a history of MI and in carefully matched controls from the Finnish population. The most common low density lipoprotein receptor mutations in Finland were also included in our analysis. Multiplex genotyping of the target genes was performed using a specific and efficient array-based minisequencing system. The 4G allele of the plasminogen activator inhibitor gene (P < 0.05) and the PlA2 allele of the glycoprotein IIIa gene (P < 0.01) were associated with an increased risk of MI in our study population. We analysed the combined effect of these risk alleles and found that the concurrent carrier status of the two genetic variants conferred a high risk for the development of MI in our sample (OR = 4.5, P = 0.001), which was particularly prominent in male subjects (OR = 6.4, P = 0.0005). This study demonstrates the application of a new powerful tool for genome analysis to yield information on the inherited determinants of susceptibility to MI. The observation of two separate genes contributing an additive risk of developing MI exemplifies the advantages of multiplex analysis of genetic variation.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
P. F. Bray, T. D. Howard, E. Vittinghoff, D. C. Sane, and D. M. Herrington
Effect of genetic variations in platelet glycoproteins Ib{alpha} and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy
Blood, March 1, 2007; 109(5): 1862 - 1869.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
V. Stangl, G. Baumann, and K. Stangl
Coronary atherogenic risk factors in women
Eur. Heart J., November 2, 2002; 23(22): 1738 - 1752.
[Full Text] [PDF]

Home page
 ChestHome page
J. B. Braunstein, D. W. Kershner, P. Bray, G. Gerstenblith, S. P. Schulman, W. S. Post, and R. S. Blumenthal
Interaction of Hemostatic Genetics With Hormone Therapy : New Insights To Explain Arterial Thrombosis in Postmenopausal Women
Chest, March 1, 2002; 121(3): 906 - 920.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. M. Boekholdt, N. R. Bijsterveld, A. H.M. Moons, M. Levi, H. R. Buller, and R. J.G. Peters
Genetic Variation in Coagulation and Fibrinolytic Proteins and Their Relation With Acute Myocardial Infarction: A Systematic Review
Circulation, December 18, 2001; 104(25): 3063 - 3068.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Herrington and K. P. Klein
Genome and Hormones: Gender Differences in Physiology: Invited Review: Pharmacogenetics of estrogen replacement therapy
J Appl Physiol, December 1, 2001; 91(6): 2776 - 2784.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
T. Pastinen, M. Perola, J. Ignatius, C. Sabatti, P. Tainola, M. Levander, A.-C. Syvanen, and L. Peltonen
Dissecting a population genome for targeted screening of disease mutations
Hum. Mol. Genet., December 1, 2001; 10(26): 2961 - 2972.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. F. O'Connor, D. C. Shields, A. Fitzgerald, C. P. Cannon, E. Braunwald, and D. J. Fitzgerald
Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes
Blood, December 1, 2001; 98(12): 3256 - 3260.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
K. Lindroos, U. Liljedahl, M. Raitio, and A.-C. Syvanen
Minisequencing on oligonucleotide microarrays: comparison of immobilisation chemistries
Nucleic Acids Res., July 1, 2001; 29(13): e69 - e69.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. S. Williams and P. F. Bray
Genetics of Arterial Prothrombotic Risk States
Experimental Biology and Medicine, May 1, 2001; 226(5): 409 - 419.
[Abstract] [Full Text]

Home page
 Genome ResHome page
M. Raitio, K. Lindroos, M. Laukkanen, T. Pastinen, P. Sistonen, A. Sajantila, and A.-C. Syvänen
Y-Chromosomal SNPs in Finno-Ugric-Speaking Populations Analyzed by Minisequencing on Microarrays
Genome Res., March 1, 2001; 11(3): 471 - 482.
[Abstract] [Full Text]

Home page
 J Am Coll CardiolHome page
J. Mikkelsson, M. Perola, P. Laippala, A. Penttila, and P. J. Karhunen
Glycoprotein IIIa PlA1/A2 polymorphism and sudden cardiac death
J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1317 - 1323.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
T. Pastinen, M. Raitio, K. Lindroos, P. Tainola, L. Peltonen, and A.-C. Syvänen
A System for Specific, High-throughput Genotyping by Allele-specific Primer Extension on Microarrays
Genome Res., July 1, 2000; 10(7): 1031 - 1042.
[Abstract] [Full Text]

Home page
 Genome ResHome page
J.-B. Fan, X. Chen, M. K. Halushka, A. Berno, X. Huang, T. Ryder, R. J. Lipshutz, D. J. Lockhart, and A. Chakravarti
Parallel Genotyping of Human SNPs Using Generic High-density Oligonucleotide Tag Arrays
Genome Res., June 1, 2000; 10(6): 853 - 860.
[Abstract] [Full Text]

Home page
 CirculationHome page
A. D. Michelson, M. I. Furman, P. Goldschmidt-Clermont, M. A. Mascelli, C. Hendrix, L. Coleman, J. Hamlington, M. R. Barnard, T. Kickler, D. J. Christie, et al.
Platelet GP IIIa PlA Polymorphisms Display Different Sensitivities to Agonists
Circulation, March 7, 2000; 101(9): 1013 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
B. T. Heijmans, R. G. J. Westendorp, D. L. Knook, C. Kluft, and P. E. Slagboom
Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort
J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1176 - 1183.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
S. Cheng, M. A. Grow, C. Pallaud, W. Klitz, H. A. Erlich, S. Visvikis, J. J. Chen, C. R. Pullinger, M. J. Malloy, G. Siest, et al.
A Multilocus Genotyping Assay for Candidate Markers of Cardiovascular Disease Risk
Genome Res., October 1, 1999; 9(10): 936 - 949.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Mikkelsson, M. Perola, P. Laippala, V. Savolainen, J. Pajarinen, K. Lalu, A. Penttila, and P. J. Karhunen
Glycoprotein IIIa PlA Polymorphism Associates With Progression of Coronary Artery Disease and With Myocardial Infarction in an Autopsy Series of Middle-Aged Men Who Died Suddenly
Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2573 - 2578.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.