Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (109)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Oka, A.
Right arrow Articles by Inoko, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oka, A.
Right arrow Articles by Inoko, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, Vol 8, 2165-2170, Copyright © 1999 by Oxford University Press

ARTICLES

Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene

A Oka, G Tamiya, M Tomizawa, M Ota, Y Katsuyama, S Makino, T Shiina, M Yoshitome, M Iizuka, Y Sasao, K Iwashita, Y Kawakubo, J Sugai, A Ozawa, M Ohkido, M Kimura, S Bahram and H Inoko
Department of Genetic Information, Division of Molecular Life Science and

The HLA-Cw6 antigen has been associated with psoriasis vulgaris despite racial and ethnic differences. However, it remains unclear whether it is the HLA-Cw6 antigen itself or a closely linked, hitherto unidentified, locus that predisposes to the disease. Here, in order to map the susceptibility locus for psoriasis vulgaris precisely within the HLA class I region, 11 polymorphic microsatellite markers distributed throughout a 1060 kb segment surrounding the HLA-C locus were subjected to association analysis in Japanese psoriasis vulgaris patients. Statistical analyses of the distribution and deviation from Hardy-Weinberg equilibrium of the allelic frequency at each micro- satellite locus revealed that the pathogenic gene for psoriasis vulgaris is located within a reduced interval of 111 kb spanning 89-200 kb telomeric of the HLA-C gene. In addition to three known genes, POU5F1, TCF19 and S, this 111 kb fragment contains four new, expressed genes identified in the course of our genomic sequencing of the entire HLA class I region. Therefore, these seven genes are the potential candidates for susceptibility to psoriasis vulgaris.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J OphthalmolHome page
M Akiyama, K Yatsu, M Ota, Y Katsuyama, K Kashiwagi, F Mabuchi, H Iijima, K Kawase, T Yamamoto, M Nakamura, et al.
Microsatellite analysis of the GLC1B locus on chromosome 2 points to NCK2 as a new candidate gene for normal tension glaucoma
Br J Ophthalmol, September 1, 2008; 92(9): 1293 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. Yatsu, N. Mizuki, N. Hirawa, A. Oka, N. Itoh, T. Yamane, M. Ogawa, T. Shiwa, Y. Tabara, S. Ohno, et al.
High-Resolution Mapping for Essential Hypertension Using Microsatellite Markers
Hypertension, March 1, 2007; 49(3): 446 - 452.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
T. Shiina, M. Ota, S. Shimizu, Y. Katsuyama, N. Hashimoto, M. Takasu, T. Anzai, J. K. Kulski, E. Kikkawa, T. Naruse, et al.
Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity
Genetics, July 1, 2006; 173(3): 1555 - 1570.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. Corbi, T. Bruno, R. De Angelis, M. Di Padova, V. Libri, M. G. Di Certo, L. Spinardi, A. Floridi, M. Fanciulli, and C. Passananti
RNA Polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product
J. Cell Sci., September 15, 2005; 118(18): 4253 - 4260.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
J. Kere
Mapping and identifying genes for asthma and psoriasis
Phil Trans R Soc B, August 29, 2005; 360(1460): 1551 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
G. Tamiya, M. Shinya, T. Imanishi, T. Ikuta, S. Makino, K. Okamoto, K. Furugaki, T. Matsumoto, S. Mano, S. Ando, et al.
Whole genome association study of rheumatoid arthritis using 27 039 microsatellites
Hum. Mol. Genet., August 15, 2005; 14(16): 2305 - 2321.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
F. Capon, M. H. Allen, M. Ameen, A. D. Burden, D. Tillman, J. N. Barker, and R. C. Trembath
A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups
Hum. Mol. Genet., October 1, 2004; 13(20): 2361 - 2368.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
C. A. Stewart, R. Horton, R. J.N. Allcock, J. L. Ashurst, A. M. Atrazhev, P. Coggill, I. Dunham, S. Forbes, K. Halls, J. M.M. Howson, et al.
Complete MHC Haplotype Sequencing for Common Disease Gene Mapping
Genome Res., June 1, 2004; 14(6): 1176 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Sugawara, H. Shimizu, N. Hoshi, A. Nakajima, and S. Fujimoto
Steroidogenic Acute Regulatory Protein-binding Protein Cloned by a Yeast Two-hybrid System
J. Biol. Chem., October 24, 2003; 278(43): 42487 - 42494.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. C. Barlow, R. G. Collins, N. J. Ball, C. T. Weaver, T. R. Schoeb, and D. C. Bullard
Psoriasiform Dermatitis Susceptibility in Itgb2tm1Bay PL/J Mice Requires Low-Level CD18 Expression and at Least Two Additional Loci for Progression to Severe Disease
Am. J. Pathol., July 1, 2003; 163(1): 197 - 202.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
F Capon, I K Toal, J C Evans, M H Allen, S Patel, D Tillman, D Burden, J N W N Barker, and R C Trembath
Haplotype analysis of distantly related populations implicates corneodesmosin in psoriasis susceptibility
J. Med. Genet., June 1, 2003; 40(6): 447 - 452.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
N. Yanagitani, T. Kohno, J.-G. Kim, H. Kunitoh, T. Tamura, Y. Takei, S. Tsuchiya, R. Saito, and J. Yokota
Identification of D19S246 as a Novel Lung Adenocarcinoma Susceptibility Locus by Genome Survey with 10-cM Resolution Microsatellite Markers
Cancer Epidemiol. Biomarkers Prev., April 1, 2003; 12(4): 366 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
T. Takada, A. Kumanovics, C. Amadou, M. Yoshino, E. P. Jones, M. Athanasiou, G. A. Evans, and K. F. Lindahl
Species-Specific Class I Gene Expansions Formed the Telomeric 1 Mb of the Mouse Major Histocompatibility Complex
Genome Res., April 1, 2003; 13(4): 589 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. I. McCarthy and P. Froguel
Genetic approaches to the molecular understanding of type 2 diabetes
Am J Physiol Endocrinol Metab, August 1, 2002; 283(2): E217 - E225.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
N. Yanagitani, T. Kohno, N. Sunaga, H. Kunitoh, T. Tamura, S. Tsuchiya, R. Saito, and J. Yokota
Localization of a human lung adenocarcinoma susceptibility locus, possibly syntenic to the mouse Pas1 locus, in the vicinity of the D12S1034 locus on chromosome 12p11.2-p12.1
Carcinogenesis, July 1, 2002; 23(7): 1177 - 1183.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
K. Asumalahti, C. Veal, T. Laitinen, S. Suomela, M. Allen, O. Elomaa, M. Moser, R. de Cid, S. Ripatti, I. Vorechovsky, et al.
Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus
Hum. Mol. Genet., March 1, 2002; 11(5): 589 - 597.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
J. T. Elder, R. P. Nair, T. Henseler, S. Jenisch, P. Stuart, N. Chia, E. Christophers, and J. J. Voorhees
The Genetics of Psoriasis 2001: The Odyssey Continues
Arch Dermatol, November 1, 2001; 137(11): 1447 - 1454.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
K. Asumalahti, T. Laitinen, R. Itkonen-Vatjus, M.-L. Lokki, S. Suomela, E. Snellman, U. Saarialho-Kere, and J. Kere
A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele
Hum. Mol. Genet., June 12, 2000; 9(10): 1533 - 1542.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Herr, F. Dudbridge, P. Zavattari, F. Cucca, C. Guja, R. March, R. D. Campbell, A. H. Barnett, S. C. Bain, J. A. Todd, et al.
Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21
Hum. Mol. Genet., May 22, 2000; 9(9): 1291 - 1301.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
D. W. Morris, L. Robinson, D. Turic, M. Duke, V. Webb, C. Milham, E. Hopkin, K. Pound, S. Fernando, M. Easton, et al.
Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q
Hum. Mol. Genet., March 22, 2000; 9(5): 843 - 848.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.