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Human Molecular Genetics, Vol 8, 195-204, Copyright © 1999 by Oxford University Press

ARTICLES

Xist RNA exhibits a banded localization on the inactive X chromosome and is excluded from autosomal material in cis

SM Duthie, TB Nesterova, EJ Formstone, AM Keohane, BM Turner, SM Zakian and N Brockdorff
X Inactivation Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK.

The propagation of X chromosome inactivation is thought to be mediated by the cis- limited spreading of the non-protein coding Xist transcript. In this report we have investigated the localization of Xist RNA on rodent metaphase chromosomes. We show that Xist RNA exhibits a banded pattern on the inactive X and is excluded from regions of constitutive heterochromatin. The banding pattern suggests a preferential association with gene-rich, G-light regions. Analysis of X:autosome rearrangements revealed that restricted propagation of X inactivation into cis -linked autosomal material is reflected by a corresponding limited spread of Xist RNA. We discuss these results in the context of models for the function of Xist RNA in the propagation of X inactivation.
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