Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (74)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Jackson, M. S.
Right arrow Articles by Archidiacono, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jackson, M. S.
Right arrow Articles by Archidiacono, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, Vol 8, 205-215, Copyright © 1999 by Oxford University Press

ARTICLES

Sequences flanking the centromere of human chromosome 10 are a complex patchwork of arm-specific sequences, stable duplications and unstable sequences with homologies to telomeric and other centromeric locations

MS Jackson, M Rocchi, G Thompson, T Hearn, M Crosier, J Guy, D Kirk, L Mulligan, A Ricco, S Piccininni, R Marzella, L Viggiano and N Archidiacono
Department of Human Genetics, University of Newcastle upon Tyne, 19/20 Claremont Place, Newcastle upon Tyne NE2 4AA, UK. mjackson@hgmp.mrc.ac.uk

Little is known about sequence organization close to human centromeres, despite empirical and theoretical data which suggest that it may be unusual. Here we present maps which physically define large sequence duplications flanking the centromeric satellites of human chromosome 10, together with a fluorescence in situ hybridization (FISH) analysis of pericentromeric sequence stability. Our results indicate that the duplications on each chromosome arm are organized into two blocks of approximately 250 and 150 kb separated by approximately 300 kb of non- duplicated DNA. The larger proximal blocks, containing ZNF11A, ZNF33A and ZNF37A (10p11) and ZNF11B, ZNF33B and ZNF37B (10q11), are inverted. However, the smaller distal blocks, containing D10S141A (10p11) and D10S141B (10q11), are not. A primate FISH analysis indicates that these loci were duplicated before the divergence of orang-utans from other Great Apes, that a cytogenetically cryptic pericentric inversion may have been involved in the formation of the flanking duplications and that they have undergone further rearrangement in other primate species. More surprising is the fact that sequences across the entire pericentromeric region appear to have undergone unprecedented levels of duplication, transposition, inversion and either deletion or sequence divergence in all primate species analysed. Extrapolating our data to the whole genome suggests that a minimum of 50 Mb of DNA in centromere- proximal regions is subject to an elevated level of mechanistically diverse sequence rearrangements compared with the bulk of genomic DNA.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Genome ResHome page
S. Kirsch, C. Munch, Z. Jiang, Z. Cheng, L. Chen, C. Batz, E. E. Eichler, and W. Schempp
Evolutionary dynamics of segmental duplications from human Y-chromosomal euchromatin/heterochromatin transition regions
Genome Res., July 1, 2008; 18(7): 1030 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
S. Lee, E. Cheran, and M. Brudno
A robust framework for detecting structural variations in a genome
Bioinformatics, July 1, 2008; 24(13): i59 - i67.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
T. L. Newman, E. Tuzun, V. A. Morrison, K. E. Hayden, M. Ventura, S. D. McGrath, M. Rocchi, and E. E. Eichler
A genome-wide survey of structural variation between human and chimpanzee
Genome Res., October 1, 2005; 15(10): 1344 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. E. Horvath, C. L. Gulden, R. U. Vallente, M. Y. Eichler, M. Ventura, J. D. McPherson, T. A. Graves, R. K. Wilson, S. Schwartz, M. Rocchi, et al.
Punctuated duplication seeding events during the evolution of human chromosome 2p11
Genome Res., July 1, 2005; 15(7): 914 - 927.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
K. Mrasek, H. Starke, and T. Liehr
Another Small Supernumerary Marker Chromosome (sSMC) Derived from Chromosome 2: Towards a Genotype/Phenotype Correlation
J. Histochem. Cytochem., March 1, 2005; 53(3): 367 - 370.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
A. M. Snijders, N. J. Nowak, B. Huey, J. Fridlyand, S. Law, J. Conroy, T. Tokuyasu, K. Demir, R. Chiu, J.-H. Mao, et al.
Mapping segmental and sequence variations among laboratory mice using BAC array CGH
Genome Res., February 1, 2005; 15(2): 302 - 311.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
S. Zhao, J. Shetty, L. Hou, A. Delcher, B. Zhu, K. Osoegawa, P. de Jong, W. C. Nierman, R. L. Strausberg, and C. M. Fraser
Human, Mouse, and Rat Genome Large-Scale Rearrangements: Stability Versus Speciation
Genome Res., October 1, 2004; 14(10a): 1851 - 1860.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
M. Ventura, S. Weigl, L. Carbone, M. F. Cardone, D. Misceo, M. Teti, P. D'Addabbo, A. Wandall, E. Bjorck, P. J. de Jong, et al.
Recurrent Sites for New Centromere Seeding
Genome Res., September 1, 2004; 14(9): 1696 - 1703.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
E. Tuzun, J. A. Bailey, and E. E. Eichler
Recent Segmental Duplications in the Working Draft Assembly of the Brown Norway Rat
Genome Res., April 1, 2004; 14(4): 493 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
M. Ventura, J. M. Mudge, V. Palumbo, S. Burn, E. Blennow, M. Pierluigi, R. Giorda, O. Zuffardi, N. Archidiacono, M. S. Jackson, et al.
Neocentromeres in 15q24-26 Map to Duplicons Which Flanked an Ancestral Centromere in 15q25
Genome Res., September 1, 2003; 13(9): 2059 - 2068.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. E. Horvath, C. L. Gulden, J. A. Bailey, C. Yohn, J. D. Mcpherson, A. Prescott, B. A. Roe, P. J de Jong, M. Ventura, D. Misceo, et al.
Using a Pericentromeric Interspersed Repeat to Recapitulate the Phylogeny and Expansion of Human Centromeric Segmental Duplications
Mol. Biol. Evol., September 1, 2003; 20(9): 1463 - 1479.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
V. Eder, M. Ventura, M. Ianigro, M. Teti, M. Rocchi, and N. Archidiacono
Chromosome 6 Phylogeny in Primates and Centromere Repositioning
Mol. Biol. Evol., September 1, 2003; 20(9): 1506 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Kost-Alimova, H. Kiss, L. Fedorova, Y. Yang, J. P. Dumanski, G. Klein, and S. Imreh
Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3
PNAS, May 27, 2003; 100(11): 6622 - 6627.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
A. Courseaux, F. Richard, J. Grosgeorge, C. Ortola, A. Viale, C. Turc-Carel, B. Dutrillaux, P. Gaudray, and J.-L. Nahon
Segmental Duplications in Euchromatic Regions of Human Chromosome 5: A Source of Evolutionary Instability and Transcriptional Innovation
Genome Res., March 1, 2003; 13(3): 369 - 381.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. Guy, T. Hearn, M. Crosier, J. Mudge, L. Viggiano, D. Koczan, H.-J. Thiesen, J. A. Bailey, J. E. Horvath, E. E. Eichler, et al.
Genomic Sequence and Transcriptional Profile of the Boundary Between Pericentromeric Satellites and Genes on Human Chromosome Arm 10p
Genome Res., February 1, 2003; 13(2): 159 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
J.A. BAILEY and E.E. EICHLER
Genome-wide Detection and Analysis of Recent Segmental Duplications within Mammalian Organisms
Cold Spring Harb Symp Quant Biol, January 1, 2003; 68(0): 115 - 124.
[Abstract] [PDF]

Home page
 Genome ResHome page
J. W. Thomas, M. G. Schueler, T. J. Summers, R. W. Blakesley, J. C. McDowell, P. J. Thomas, J. R. Idol, V. V.B. Maduro, S.-Q. Lee-Lin, J. W. Touchman, et al.
Pericentromeric Duplications in the Laboratory Mouse
Genome Res., January 1, 2003; 13(1): 55 - 63.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
I. Cserpan, R. Katona, T. Praznovszky, E. Novak, M. Rozsavolgyi, E. Csonka, M. Morocz, K. Fodor, and G. Hadlaczky
The chAB4 and NF1-related long-range multisequence DNA families are contiguous in the centromeric heterochromatin of several human chromosomes
Nucleic Acids Res., July 1, 2002; 30(13): 2899 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
J A Fantes, S K Mewborn, C M Lese, J Hedrick, R L Brown, V Dyomin, R S K Chaganti, S L Christian, and D H Ledbetter
Organisation of the pericentromeric region of chromosome 15: at least four partial gene copies are amplified in patients with a proximal duplication of 15q
J. Med. Genet., March 1, 2002; 39(3): 170 - 177.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
M. Crosier, L. Viggiano, J. Guy, D. Misceo, R. Stones, W. Wei, T. Hearn, M. Ventura, N. Archidiacono, M. Rocchi, et al.
Human Paralogs of KIAA0187 Were Created through Independent Pericentromeric-Directed and Chromosome-Specific Duplication Mechanisms
Genome Res., January 1, 2002; 12(1): 67 - 80.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. E. Horvath, J. A. Bailey, D. P. Locke, and E. E. Eichler
Lessons from the human genome: transitions between euchromatin and heterochromatin
Hum. Mol. Genet., October 1, 2001; 10(20): 2215 - 2223.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
T. K. Footz, P. Brinkman-Mills, G. S. Banting, S. A. Maier, M. A. Riazi, L. Bridgland, S. Hu, B. Birren, S. Minoshima, N. Shimizu, et al.
Analysis of the Cat Eye Syndrome Critical Region in Humans and the Region of Conserved Synteny in Mice: A Search for Candidate Genes at or near the Human Chromosome 22 Pericentromere
Genome Res., June 1, 2001; 11(6): 1053 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
L. H. Wong and K. H. A. Choo
Centromere on the Move
Genome Res., April 1, 2001; 11(4): 513 - 516.
[Full Text]

Home page
 Genome ResHome page
M. Ventura, N. Archidiacono, and M. Rocchi
Centromere Emergence in Evolution
Genome Res., April 1, 2001; 11(4): 595 - 599.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. L. Kolnicki
Kinetochore reproduction in animal evolution: Cell biological explanation of karyotypic fission theory
PNAS, August 15, 2000; 97(17): 9493 - 9497.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Guy, C. Spalluto, A. McMurray, T. Hearn, M. Crosier, L. Viggiano, V. Miolla, N. Archidiacono, M. Rocchi, C. Scott, et al.
Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10q
Hum. Mol. Genet., August 12, 2000; 9(13): 2029 - 2042.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. E. Horvath, S. Schwartz, and E. E. Eichler
The Mosaic Structure of Human Pericentromeric DNA: A Strategy for Characterizing Complex Regions of the Human Genome
Genome Res., June 1, 2000; 10(6): 839 - 852.
[Abstract] [Full Text]

Home page
 Genome ResHome page
Y. Ji, E. E. Eichler, S. Schwartz, and R. D. Nicholls
Structure of Chromosomal Duplicons and their Role in Mediating Human Genomic Disorders
Genome Res., May 1, 2000; 10(5): 597 - 610.
[Abstract] [Full Text]

Home page
 Hum Mol GenetHome page
J. E. Horvath, L. Viggiano, B. J. Loftus, M. D. Adams, N. Archidiacono, M. Rocchi, and E. E. Eichler
Molecular structure and evolution of an alpha satellite/non-alpha satellite junction at 16p11
Hum. Mol. Genet., January 1, 2000; 9(1): 113 - 123.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
G. Montefalcone, S. Tempesta, M. Rocchi, and N. Archidiacono
Centromere Repositioning
Genome Res., December 1, 1999; 9(12): 1184 - 1188.
[Abstract] [Full Text]

Home page
 Genome ResHome page
E. E. Eichler, N. Archidiacono, and M. Rocchi
CAGGG Repeats and the Pericentromeric Duplication of the Hominoid Genome
Genome Res., November 1, 1999; 9(11): 1048 - 1058.
[Abstract] [Full Text]

Home page
 Genome ResHome page
J. A. Bailey, A. M. Yavor, H. F. Massa, B. J. Trask, and E. E. Eichler
Segmental Duplications: Organization and Impact Within the Current Human Genome Project Assembly
Genome Res., June 1, 2001; 11(6): 1005 - 1017.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.