Human Molecular Genetics, Vol 8, 601-605, Copyright © 1999 by Oxford University Press
Y Zhang, J Lefort, V Kearsey, JR Lapa e Silva, WO Cookson and BB Vargaftig
Asthma is the most common illness of childhood, affecting one child in
seven in the UK. Asthma has a genetic basis, but genetic studies of asthma
in humans are confounded by uncontrolled environmental factors, varying
penetrance and phenotypic pleiotropy. An animal model of asthma would offer
controlled exposure, limited and consistent genetic variation, and
unlimited size of sibships. Following immunization and subsequent challenge
with ovalbumin, the Biozzi BP2 mouse shows features of asthma, including
airway inflammation, eosinophil infiltration and non-specific bronchial
responsiveness. In order to identify genetic loci influencing these traits,
a cross was made between BP2 and BALB/c mice, and a genome-wide screen
carried out in the F2progeny of the F1intercross. Five potentially linked
loci were identified, four of which corresponded to human regions of
syntenic homology that previously have shown linkage to asthma-associated
traits.
ARTICLES
A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma
Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK.
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