Human Molecular Genetics, Vol 8, 611-619, Copyright © 1999 by Oxford University Press
AL Brown and GF Kay
Parthenogenetic and normal blastocysts were compared using differential
display analysis as a means to identify new imprinted genes. A single gene
was identified with increased expression in parthenogenetic blastocysts,
suggesting it might be an imprinted gene expressed from the maternally
inherited allele. The gene, named Bex1 (brainexpressedX- linked gene), maps
near Plp on the mouse X chromosome and to Xq22 in humans. Database homology
searches revealed two additional uncharacterized cDNAs similar to Bex1 that
were named Bex2 and Bex3. Allele-specific expression analysis of Bex1 using
F1 blastocysts indicated an excess of transcript expressed from the
maternally inherited allele compared with the paternally inherited allele.
This excess level of transcript derived from the maternally inherited
allele may be due to imprinted X inactivation of the paternally inherited
allele in the extraembryonic lineages of female embryos rather than a
result of genomic imprinting.
ARTICLES
Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome [published erratum appears in Hum Mol Genet 1999 May;8(5):943]
QCF Transgenic Laboratory, Joint Experimental Oncology Program, The Queensland Institute of Medical Research and The University of Queensland, PO Royal Brisbane Hospital, Queensland 4029, Australia.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Naderi, A. E. Teschendorff, J. Beigel, M. Cariati, I. O. Ellis, J. D. Brenton, and C. Caldas BEX2 Is Overexpressed in a Subset of Primary Breast Cancers and Mediates Nerve Growth Factor/Nuclear Factor-{kappa}B Inhibition of Apoptosis in Breast Cancer Cell Lines Cancer Res., July 15, 2007; 67(14): 6725 - 6736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Han, H. Liu, J. Liu, K. Yin, Y. Xie, X. Shen, Y. Wang, J. Yuan, B. Qiang, Y.-J. Liu, et al. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex Nucleic Acids Res., November 24, 2005; 33(20): 6555 - 6565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Mould, S. A. Greco, M. M. Cahill, I. D. Tonks, D. Bellomo, C. Patterson, A. Zournazi, A. Nash, P. Scotney, N. K. Hayward, et al. Transgenic Overexpression of Vascular Endothelial Growth Factor-B Isoforms by Endothelial Cells Potentiates Postnatal Vessel Growth In Vivo and In Vitro Circ. Res., September 16, 2005; 97(6): e60 - e70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mukai, S. Shoji, M. T. Kimura, S. Okubo, H. Sano, P. Suvanto, Y. Li, S. Irie, and T.-A. Sato Structure-Function Analysis of NADE. IDENTIFICATION OF REGIONS THAT MEDIATE NERVE GROWTH FACTOR-INDUCED APOPTOSIS J. Biol. Chem., April 12, 2002; 277(16): 13973 - 13982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Kimura, S. Irie, S. Shoji-Hoshino, J. Mukai, D. Nadano, M. Oshimura, and T.-A. Sato 14-3-3 Is Involved in p75 Neurotrophin Receptor-mediated Signal Transduction J. Biol. Chem., May 11, 2001; 276(20): 17291 - 17300. [Abstract] [Full Text] [PDF]
|
|